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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3S0209 | Vincristine | ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR | |
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato... | |||
T1270 | Vincristine sulfate | Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate | Apoptosis , Microtubule Associated |
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle. | |||
T38699 | Piperafizine A | ||
Piperafizine A is isolated from Streptoverticillium aspergilloides and potentiates vincristine antitumor potency. | |||
T10991 | Dehydronitrosonisoldipine | Calcium Channel | |
Dehydronitrosonisoldipine is an inhibitor of sterile α and TIR motif-containing 1 and can be used in studies about neurodegenerative disorders. Dehydronitrosonisoldipine inhibits axon degenration and the Vincristine-acti... | |||
T34645 | Simetride | ||
Simetride is used in the Reversal of resistance to vincristine in P388 leukemia. | |||
T33510 | MS-073 | CP162398,CP-162398,CP 162398,MS 073 | |
MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, an... | |||
T75642 | Corydalmine hydrochloride | ||
Corydalmine hydrochloride is a chemical compound that suppresses spore germination in certain plant pathogenic and saprophytic fungi [1], serves as an effective oral analgesic agent with potent activity [2], and mitigate... | |||
TN4962 | Scholaricine | Others | |
Scholaricine reverses multidrug resistance in vincristine-resistant KB cells. | |||
T26413 | A 30312 | A-30312,A30312 | |
A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with... | |||
T68209 | Kopsoffinol | ||
Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine... | |||
T63608 | P-gp inhibitor 5 | ||
P-gp inhibitor 5 is a potent inhibitor of P-glycoprotein (P-gp), inhibiting P-gp by a factor of 2.5 and 3.0 at 1.25 μM and 2.5 μM, respectively. p-gp inhibitor 5 exhibits anti-proliferative effects on some cancer cells. ... | |||
T37851 | Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) | ||
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N... | |||
T64061 | Mps1-IN-3 hydrochloride | ||
Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1 (IC50: 50 nM). mps1-IN-3 hydrochloride exhibits inhibitory effects on the proliferation of glioblastoma cells and effectively sensitizes glioblastomas t... | |||
TN5414 | Wallichinine | ||
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural p... | |||
T35616 | Migrastatin | ||
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectiv... | |||
T22631 | Dolastatin 10 trifluoroacetate | Others | |
Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerizati... | |||
T71252 | PC-046 | ||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... |