Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | Inquiry | $ 477.00 | |
5 mg | Inquiry | $ 1,175.00 |
Description | Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding. |
In vitro | In the cellular assay, Dolastatin 10 shows activity against some human leukaemia, lymphoma, and solid tumor cell lines (such as OVCAR-3 and NSCLC) with IC50 values ranging from 0.1nM to 10nM. It is currently tested in clinical trials [2]. |
Molecular Weight | 899.11 |
Formula | C44H69F3N6O8S |
CAS No. | T22631 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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Dolastatin 10 trifluoroacetate T22631 Others Dolastatin 10 Trifluoroacetate inhibitor inhibit