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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13233 | Tyk2-IN-3 | Tyrosine Kinases | |
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM). | |||
T64265 | JAK1/TYK2-IN-3 | ||
JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 ... | |||
T2638 | Gandotinib | LY2784544 | VEGFR , FGFR , FLT , JAK |
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3. | |||
T2636 | Decernotinib | VX-509,VRT-831509 | Tyrosine Kinases , JAK |
Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. | |||
T11704 | JAK-IN-3 | CCR | |
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. | |||
T73392 | TUL01101 | ||
TUL01101, a potent, selective, and orally active inhibitor of JAK1, exhibits half-maximal inhibitory concentrations (IC50s) of 3 nM for JAK1, 37 nM for JAK2, 1,517 nM for JAK3, and 36 nM for TYK2. This compound is utiliz... |