Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,570.00 | |
50 mg | 10-14 weeks | $ 3,380.00 | |
100 mg | 10-14 weeks | $ 4,600.00 |
Description | Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM). |
Targets&IC50 | TYK2:485 nM |
In vivo | Tyk2-IN-3 is very potent Tyk2 pseudokinase against (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3). |
Molecular Weight | 520.63 |
Formula | C25H24N6O3S2 |
CAS No. | 1779493-12-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tyk2-IN-3 1779493-12-7 Tyrosine Kinase/Adaptors Tyrosine Kinases Tyk2 IN 3 Tyk2IN3 Tyk-2-IN-3 inhibitor inhibit