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Tyk2-IN-3

Catalog No. T13233 CAS 1779493-12-7

Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).

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Tyk2-IN-3, CAS 1779493-12-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
Targets&IC50	Tyk2:485 nM
In vivo	Tyk2-IN-3 is very potent Tyk2 pseudokinase against (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3).

Molecular Weight	520.63
Formula	C25H24N6O3S2
CAS No.	1779493-12-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tokarski JS, et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J Biol Chem. 2015 Apr 24;290(17):11061-74.

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Keywords

Tyk2-IN-3 1779493-12-7 蛋白酪氨酸激酶 Tyrosine Kinases Tyk2 IN 3 Tyk2IN3 Tyk-2-IN-3 Inhibitor inhibitor inhibit

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