Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
Description | Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM). |
Targets&IC50 | Tyk2:485 nM |
In vivo | Tyk2-IN-3 is very potent Tyk2 pseudokinase against (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3). |
Molecular Weight | 520.63 |
Formula | C25H24N6O3S2 |
CAS No. | 1779493-12-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tyk2-IN-3 1779493-12-7 蛋白酪氨酸激酶 Tyrosine Kinases Tyk2 IN 3 Tyk2IN3 Tyk-2-IN-3 Inhibitor inhibitor inhibit