Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 312.00 | |
100 mg | In stock | $ 493.00 | |
500 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3. |
Targets&IC50 | JAK2:3 nM, JAK2V617F:0.245 nM(Ki) |
Cell Research | LY2784544 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. Ba/F3 cells expressing JAK2V617F are placed in RPMI-1640-containing vehicle (DMSO) or LY2784544 (concentration range, 0.001-20 μM) (1×104 cells/96-well). Ba/F3 cells expressing wild-type JAK2 are treated similarly except IL-3 (2 ng/mL) is added. After a 72-hour incubation, cell proliferation is assessed by adding Cell Titer 96 Aqueous One Solution Reagent (20 μL/well). The IC50 for inhibition of cell proliferation is calculated using the GraphPad Prism 4 software[1]. |
Synonyms | LY2784544 |
Molecular Weight | 469.94 |
Formula | C23H25ClFN7O |
CAS No. | 1229236-86-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 87 mg/mL (185.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 9 mg/mL (19.15 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Gandotinib 1229236-86-5 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors FGFR VEGFR FLT JAK LY2784544 LY-2784544 inhibit LY 2784544 Janus kinase CD135 FLT3 Cluster of differentiation antigen 135 Inhibitor Fms like tyrosine kinase 3 Vascular endothelial growth factor receptor Fibroblast growth factor receptor inhibitor