Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

JAK-IN-3

🥰Excellent
Catalog No. T11704Cas No. 1400876-94-9

JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.

JAK-IN-3

JAK-IN-3

🥰Excellent
Purity: 98.19%
Catalog No. T11704Cas No. 1400876-94-9
JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$135In StockIn Stock
2 mg$198In StockIn Stock
5 mg$338In StockIn Stock
10 mg$546In StockIn Stock
25 mg$1,090In StockIn Stock
50 mg$1,730In StockIn Stock
100 mg$2,820-In Stock
200 mg$3,780-In Stock
1 mL x 10 mM (in DMSO)$372In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:98.19%
Contact us for more batch information

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity
Description
JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.
Targets&IC50
JAK3:3 nM, TYK2:34 nM, JAK1:5 nM, JAK2:70 nM
In vitro
JAK-IN-3 is a potent JAK inhibitor with IC50 values of 3 nM, 5 nM, 34 nM, and 70 nM for JAK3, JAK1, TYK2, and JAK2, respectively. [1]
Chemical Properties
Molecular Weight340.38
FormulaC18H20N4O3
Cas No.1400876-94-9
SmilesN([C@@H]([C@@H](C)O)CO)C=1C=2N(C=C(C2)C3=CC=CC=C3)N=CC1C(N)=O
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (146.89 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9379 mL14.6895 mL29.3789 mL146.8946 mL
5 mM0.5876 mL2.9379 mL5.8758 mL29.3789 mL
10 mM0.2938 mL1.4689 mL2.9379 mL14.6895 mL
20 mM0.1469 mL0.7345 mL1.4689 mL7.3447 mL
50 mM0.0588 mL0.2938 mL0.5876 mL2.9379 mL
100 mM0.0294 mL0.1469 mL0.2938 mL1.4689 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tyk2JAK-IN-3JAKIN3JAK3JAK2JAK1JAK IN 3JAK
Related Tags: buy JAK-IN-3 | purchase JAK-IN-3 | JAK-IN-3 cost | order JAK-IN-3 | JAK-IN-3 chemical structure | JAK-IN-3 in vitro | JAK-IN-3 formula | JAK-IN-3 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.