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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T77786 | TGFβ-IN-5 | WAY-641966 | TGF-beta/Smad |
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling. | |||
T60596 | TGFβ-IN-1 | ||
TGFβ-IN-1 is an antitumor growth and metastasis agent by inhibiting the transforming growth factor β signaling pathway. | |||
T61586 | TGFβ-IN-2 | ||
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and ... | |||
T21714 | BMS453 | BMS 453,BMS-189453 | Retinoid Receptor |
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. | |||
T6496 | Vactosertib | TEW-7197,EW-7197 | ALK , TGF-beta/Smad |
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... | |||
T9523 | TGFβRI-IN-3 | TGF-beta/Smad | |
TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1]. | |||
T75005 | TGFβ1-IN-3 | Others | |
TGFβ1-IN-3 is a diarylhydrazone derivative with inhibitory effects on fibroblast activation and proliferation.TGFβ1-IN-3 is a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF). | |||
T75004 | TGFβ1-IN-2 | Others | |
TGFβ1-IN-2, a derivative of diarylacylhydrazones, effectively inhibits fibroblast activation and proliferation and holds potential for idiopathic pulmonary fibrosis (IPF) research [1]. | |||
T61389 | TGFβ1-IN-1 | ||
TGFβ1-IN-1 (compound 42), an orally active, potent inhibitor of TGF-β1, suppresses the upregulation of fibrosis markers α-SMA and fibronectin, showcasing its utility in the study of liver fibrosis disease [1]. | |||
T13137 | TGFβRI-IN-1 | TGF-beta/Smad | |
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ). | |||
T62559 | TGFβRI-IN-4 | ||
TGFβRI-IN-4 is a potent, orally active TGFβ receptor type I kinase (TGFβRI) inhibitor that acts on ALK5 (IC50: 44 nM) and NIH3T3 (IC50: 42.5 nM).TGFβRI-IN-4 inhibits tumor growth and tumor weight in a xenograft tumor mod... | |||
T72976 | TGFβRI-IN-6 | ||
TGFβRI-IN-6 is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM.TGFβRI-IN-6 has the potential to enhance anti-tumour immunity. | |||
T60931 | TGFβRI-IN-5 | ||
TGFβRI-IN-5 (Compound 4b) is a potent TGFβRI inhibitor with an IC50 of 0.08 μM. TGFβRI-IN-5 shows amazing anticancer activity against all the tested cell lines which enhances apoptosis and arrested G2/M phase of cell cyc... | |||
T74163 | TGFβR-IN-1 | ||
TGFβR-IN-1 is a long-acting tumor-activated proagent of a TGFβR inhibitor. | |||
T2273 | ITD-1 | TGF-beta/Smad | |
ITD-1 is a potent and highly selective TGFβ pathway inhibitor. | |||
T5197 | BIBF0775 | ALK , TGF-beta/Smad | |
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). | |||
T61301 | Chromenone 1 | TGF-beta/Smad | |
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs. | |||
T35896 | AZ 12799734 | AZ12799734 | ALK |
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours. | |||
T2247 | KenPaullone | 9-Bromopaullone,NSC-664704 | GSK-3 , CDK |
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... | |||
T8730 | BMS986260 | TGF-beta/Smad | |
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM). |