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Search Results for " sphingosine-1-phosphate "

20

Compounds

Cat No. Product Name Synonyms Targets
T21500 Sphingosine-1-phosphate S1P Endogenous Metabolite , S1P Receptor , LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei...
T37955 Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO...
T6923 Ozanimod RPC-1063 S1P Receptor , LPL Receptor
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...
T83880 C18 Ceramide-1-phosphate (d18:1/18:0) ammonium Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin known to promote the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (H...
T83910 S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem...
T27106 CYM50374
CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.
T27864 LX-2931 LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305 S1P Receptor
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
T10305 Amiselimod hydrochloride MT-1303 hydrochloride S1P Receptor , LPL Receptor
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
TQ0227 Etrasimod APD334 S1P Receptor , LPL Receptor
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T12086 Mocravimod hydrochloride KRP-203 Others , LPL Receptor
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
T7360 GSK2018682 S1P Receptor , LPL Receptor
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T15031 CYM50260 Others , LPL Receptor
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
T7939 Fingolimod FTY-720A,FTY-720 S1P Receptor , PAK , LPL Receptor
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T9464 CYM50358 LPL Receptor
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
T14924 Cenerimod ACT-334441 S1P Receptor
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm...
T63047 SLP9101555 S1P Receptor , LPL Receptor
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace...
T10385 ASP-4058 S1P Receptor , LPL Receptor
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.
T3258 Ponesimod ACT-128800 S1P Receptor , LPL Receptor
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
T22102 ML-178 CYM50179 Others
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
T2539 Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720 TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).

Compounds

Sphingosine-1-phosphate
T21500
Synonym: S1P
Target: Endogenous Metabolite, S1P Receptor, LPL Receptor
Sphingosine-1-phosphate (d16:1)
T37955
Synonym: Sphingosine-1-phosphate (d16:1)
Target:
Ozanimod
T6923
Synonym: RPC-1063
Target: S1P Receptor, LPL Receptor
C18 Ceramide-1-phosphate (d18:1/18:0) ammonium
T83880
Synonym: Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
Target:
S1PL-IN-31
T83910
Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
Target:
CYM50374
T27106
Synonym:
Target:
LX-2931
T27864
Synonym: LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305
Target: S1P Receptor
Amiselimod hydrochloride
T10305
Synonym: MT-1303 hydrochloride
Target: S1P Receptor, LPL Receptor
Etrasimod
TQ0227
Synonym: APD334
Target: S1P Receptor, LPL Receptor
Mocravimod hydrochloride
T12086
Synonym: KRP-203
Target: Others, LPL Receptor
GSK2018682
T7360
Synonym:
Target: S1P Receptor, LPL Receptor
CYM50260
T15031
Synonym:
Target: Others, LPL Receptor
Fingolimod
T7939
Synonym: FTY-720A,FTY-720
Target: S1P Receptor, PAK, LPL Receptor
CYM50358
T9464
Synonym:
Target: LPL Receptor
Cenerimod
T14924
Synonym: ACT-334441
Target: S1P Receptor
SLP9101555
T63047
Synonym:
Target: S1P Receptor, LPL Receptor
ASP-4058
T10385
Synonym:
Target: S1P Receptor, LPL Receptor
Ponesimod
T3258
Synonym: ACT-128800
Target: S1P Receptor, LPL Receptor
ML-178
T22102
Synonym: CYM50179
Target: Others
Fingolimod hydrochloride
T2539
Synonym: Fingolimod (FTY720) HCl,FTY720
Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor
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TargetMol