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CYM50260

Catalog No. T15031   CAS 1355026-60-6

CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

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CYM50260 Chemical Structure
CYM50260, CAS 1355026-60-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
5 mg In stock $ 113.00
10 mg In stock $ 189.00
25 mg In stock $ 396.00
50 mg In stock $ 593.00
100 mg In stock $ 843.00
1 mL * 10 mM (in DMSO) In stock $ 125.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
Targets&IC50 S1P4-R:(EC50)45 nM
In vitro CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].
Molecular Weight 350.6
Formula C14H11Cl3FNO2
CAS No. 1355026-60-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (142.61 mM)

TargetMolReferences and Literature

1. Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. 2. Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max GPCR Compound Library Bioactive Compound Library

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Keywords

CYM50260 1355026-60-6 GPCR/G Protein Others LPL Receptor Inhibitor Lysophospholipid Receptor analysis inhibit S1P4-R aggregation SAR CYM-50260 platelet HSP27 PDGF-AB CYM 50260 synthetic inhibitor

 

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