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CYM50260

Catalog No. T15031 CAS 1355026-60-6

CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

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CYM50260, CAS 1355026-60-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
Targets&IC50	S1P4-R:（EC50）45 nM
In vitro	CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].

Molecular Weight	350.6
Formula	C14H11Cl3FNO2
CAS No.	1355026-60-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. 2. Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.

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Keywords

CYM50260 1355026-60-6 G蛋白偶联受体其他 LPL Receptor Others Inhibitor CYM 50260 Lysophospholipid Receptor analysis inhibit S1P4-R aggregation SAR platelet CYM-50260 HSP27 PDGF-AB synthetic inhibitor

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