Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
Description | CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
Targets&IC50 | S1P4-R:(EC50)45 nM |
In vitro | CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2]. |
Molecular Weight | 350.6 |
Formula | C14H11Cl3FNO2 |
CAS No. | 1355026-60-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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CYM50260 1355026-60-6 G蛋白偶联受体 其他 LPL Receptor Others Inhibitor CYM 50260 Lysophospholipid Receptor analysis inhibit S1P4-R aggregation SAR platelet CYM-50260 HSP27 PDGF-AB synthetic inhibitor