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CYM50260

CYM50260
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Purity:99.88%
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CYM50260

Catalog No. T15031Cas No. 1355026-60-6
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
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Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$113In Stock
10 mg$189In Stock
25 mg$396In Stock
50 mg$593In Stock
100 mg$843In Stock
1 mL x 10 mM (in DMSO)$125In Stock
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Product Introduction

Bioactivity
Description
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
In vitro
CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].
Chemical Properties
Molecular Weight350.6
FormulaC14H11Cl3FNO2
Cas No.1355026-60-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (142.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8523 mL14.2613 mL28.5225 mL142.6127 mL
5 mM0.5705 mL2.8523 mL5.7045 mL28.5225 mL
10 mM0.2852 mL1.4261 mL2.8523 mL14.2613 mL
20 mM0.1426 mL0.7131 mL1.4261 mL7.1306 mL
50 mM0.0570 mL0.2852 mL0.5705 mL2.8523 mL
100 mM0.0285 mL0.1426 mL0.2852 mL1.4261 mL

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