Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 396.00 | |
50 mg | In stock | $ 593.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
Targets&IC50 | S1P4-R:(EC50)45 nM |
In vitro | CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2]. |
Molecular Weight | 350.6 |
Formula | C14H11Cl3FNO2 |
CAS No. | 1355026-60-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (142.61 mM)
You can also refer to dose conversion for different animals. More
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CYM50260 1355026-60-6 GPCR/G Protein Others LPL Receptor Inhibitor Lysophospholipid Receptor analysis inhibit S1P4-R aggregation SAR CYM-50260 platelet HSP27 PDGF-AB CYM 50260 synthetic inhibitor