sphk2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63017	SphK2-IN-2
	SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).
T63618	SphK2-IN-1
	SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.
TQ0138	K145 hydrochloride		Apoptosis , S1P Receptor
	K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.		Apoptosis , S1P Receptor
T6750	Opaganib	ABC294640	S1P Receptor
	Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).		S1P Receptor
T63047	SLP9101555		S1P Receptor , LPL Receptor
	SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace...		S1P Receptor , LPL Receptor
T8840	PF-543 hydrochloride	PF-543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T16128	MP-A08		S1P Receptor
	MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).		S1P Receptor
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T11739	K145		Others
	K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 ...		Others
T28806	SLM6031434 HCl	SLM 6031434,SLM6031434,SLM-6031434
	SLM6031434 is selective inhibitor of SphK2.
T28803	SLC5111312 HCl	SLC5111312 hydrochloride,SLC 5111312,SLC-5111312,SLC5111312
	SLC5111312 is an inhibitor of SphK1 and SphK2.
T28802	SLC4101431	SLC-4101431,SLC 4101431
	SLC4101431 is a potent SphK2 inhibitor with Ki value of 90 nM.
T70071	SLM6031434 (free base)
	SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.
T83883	Biotin Sphingosine	Biotinyl Sphingosine
	Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates.
T63132	Amgen-23
	Amgen-23 (compound 23) is a potent inhibitor of sphingosine kinase (SPHK), acting on SPHK1 (IC50: 20 μM) and SPHK2 (IC50: 1.6 μM). amgen-23 can be used in anticancer studies.
T63835	SphK1-IN-2
	SphK1-IN-2 is a potent and selective SphK1 inhibitor that acts on both SphK1 (IC50: 19.81 nM) and SphK2 (IC50>10 nM). sphK1-IN-2 induces cell cycle arrest and apoptosis, exhibits anti-proliferative effects, and can be us...
T70900	VT-ME6
	VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residu...