Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 68.00 | |
25 mg | In stock | $ 97.00 | |
50 mg | In stock | $ 135.00 |
Description | K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. |
Targets&IC50 | SphK2:4.30 μM, SphK2:6.4 µM(Ki) |
In vitro | K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 uM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 uM for SphK2 and indicated that K145 is a substrate competitive inhibitor (with sphingosine). K145 accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways. |
Molecular Weight | 384.92 |
Formula | C18H25ClN2O3S |
CAS No. | 1449240-68-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 125 mg/mL (324.74 mM), sonification/heating is recommended.
H2O: 125 mg/mL (324.74 mM), sonification/heating is recommended.
DMSO: 48 mg/mL (124.7 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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K145 hydrochloride 1449240-68-9 Apoptosis GPCR/G Protein S1P Receptor K-145 K 145 ERK K145 Sphingosine kinase K145 Hydrochloride anti-proliferative SphK Akt sphingosine inhibit oral SphK2 K 145 Hydrochloride K-145 Hydrochloride substrate-competitive K-145 hydrochloride Inhibitor antitumor apoptotic S1P inhibitor