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K145 hydrochloride

Catalog No. TQ0138   CAS 1449240-68-9

K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.

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K145 hydrochloride Chemical Structure
K145 hydrochloride, CAS 1449240-68-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 68.00
25 mg In stock $ 97.00
50 mg In stock $ 135.00
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Purity: 99.09%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
Targets&IC50 SphK2:4.30 μM, SphK2:6.4 µM(Ki)
In vitro K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 uM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 uM for SphK2 and indicated that K145 is a substrate competitive inhibitor (with sphingosine). K145 accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways.
Molecular Weight 384.92
Formula C18H25ClN2O3S
CAS No. 1449240-68-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 125 mg/mL (324.74 mM), sonification/heating is recommended.

H2O: 125 mg/mL (324.74 mM), sonification/heating is recommended.

DMSO: 48 mg/mL (124.7 mM), sonification is recommended.

TargetMolReferences and Literature

1. Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471.

TargetMolCitations

1. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max GPCR Compound Library Orally Active Compound Library Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library

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Keywords

K145 hydrochloride 1449240-68-9 Apoptosis GPCR/G Protein S1P Receptor K-145 K 145 ERK K145 Sphingosine kinase K145 Hydrochloride anti-proliferative SphK Akt sphingosine inhibit oral SphK2 K 145 Hydrochloride K-145 Hydrochloride substrate-competitive K-145 hydrochloride Inhibitor antitumor apoptotic S1P inhibitor

 

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