sglt1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39966	SGLT1/2-IN-2	SGLT1/2-IN-2
	SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).
T62830	SGLT1/2-IN-1
	SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T15656	KGA-2727		SGLT
	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA...		SGLT
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T16083	Mizagliflozin	GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT
	Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...		SGLT
T8753	LX-2761 intermediate		Others
	LX-2761 intermediate is a synthetic intermediate of LX-2761, a chemically stable and potent SGLT1/2 inhibitor.		Others
T8750	LX-4211 intermediate		Others
	LX-4211 intermediate is a synthetic intermediate of LX-4211, a potent SGLT1/2 inhibitor used as an antidiabetic agent.		Others
T2385	Ipragliflozin	ASP1941	SGLT
	Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.		SGLT
T7217	Bexagliflozin	THR-1442,EGT1442,EGT0001442	SGLT
	Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively		SGLT
T1782L	Canagliflozin hemihydrate	JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754	SGLT
	Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab...		SGLT
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T34286	Remogliflozin etabonate	GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A	SGLT
	Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.		SGLT
T15797	LX2761		Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the...		Others
T12892	SGL5213		SGLT
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.		SGLT
T28659	SAR-7226 Hydrate	SAR7226,SAR 7226,SAR-7226
	SAR-7226 Hydrate, a SGLT1/2 inhibitor, is used potentially for the treatment of type 2 diabetes.
T15752	Licogliflozin	LIK066	SGLT
	Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).		SGLT
T32058	Henagliflozin	SHR3824,SHR 3824,SHR-3824
	Henagliflozin (SHR3824) is an effective, oral, and selective SGLT2 inhibitor that effectively inhibits human SGLT2 in vitro, but has very weak inhibitory effects on human SGLT1.
T2922	Phlorizin	Floridzin,NSC 2833,Phloridzin	ATPase , SGLT
	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .		ATPase , SGLT
T11667	Ipragliflozin (L-Proline)	Ipragliflozin L-Proline	Others
	Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.		Others