serd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12832	Amcenestrant	SAR439859	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T9997	GLL 398		Estrogen Receptor/ERR
	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.		Estrogen Receptor/ERR
T2243	Serdemetan	JNJ-26854165	Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
	Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.		Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
T39727	ERα degrader-2		ERK
	ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prev...		ERK
T13674	Elacestrant	RAD1901	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T13675	Elacestrant dihydrochloride	RAD1901 dihydrochloride	Estrogen/progestogen Receptor
	Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively.		Estrogen/progestogen Receptor
T70179	THIQ-40
	THIQ-40 is a novel potent erα antagonist and selective estrogen receptor degrader (serd), exhibiting good oral bioavailability, antitumor efficacy, and serd activity in vivo
T39118	AZD9496 maleate
	AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor...
T77724	OBHSA	Oxabicycloheptane sulfonamide	Estrogen/progestogen Receptor
	OBHSA（Oxabicycloheptane sulfonamide） is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.		Estrogen/progestogen Receptor
T63674	Imlunestrant
	Imlunestrant is a selective, orally active estrogen receptor degrader (SERD) that can be used in ER+ and HER2 breast cancer studies.
T39499	Rintodestrant	G1T48
	Rintodestrant (G1T48) is an orally active, non-steroidal, selective estrogen receptor degrader (SERD) that also functions as a CDK4/6 inhibitor.
T39368	GNE-149
	GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds poten...
T74593	Taragarestrant meglumine
	Taragarestrant (D-0502) meglumine is a potent, orally active, and selective estrogen receptor degrader (SERD) demonstrating significant efficacy in ER+ breast cancer cell lines and xenograft models [1] [2].
T74415	Imlunestrant tosylate
	Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent...
T27289	Etacstil	GW 5638,GW-5638,GW5638,DPC974,DPC 974,DPC-974
	GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. G...