rna-polymerases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8647	BCH001		DNA/RNA Synthesis
	BCH001 is a specific small-molecule inhibitor of PAPD5.		DNA/RNA Synthesis
T5539	GS-443902		Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T9618	HeE1-2Tyr		SARS-CoV
	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.		SARS-CoV
T5288	Cytidine-5'-triphosphate disodium	CTP,Cytidine 5'-triphosphate (disodium salt)	Others , Endogenous Metabolite
	Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases...		Others , Endogenous Metabolite
T7004	Tubercidin	Sparsomycin A,7-Deazaadenosine	Influenza Virus , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhib...
T4010	Juglone	5-Hydroxy-1,4-naphthoquinone,Regianin	DNA/RNA Synthesis , Antibacterial
	Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin fam...		DNA/RNA Synthesis , Antibacterial
T16945	Streptolydigin	Portamycin	Antibacterial
	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki...		Antibacterial
T38761	GS-443902 trisodium	GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
	GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concen...
T40359	Thio-ITP	6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate
	Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I...
T35657	3'-Deoxyuridine-5'-triphosphate
	3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that not only inhibits DNA-dependent RNA polymerases I and II, but also competitively and strongly inhibits the incorporation of UTP into RNA, exhibiting...
T35658	3'-Deoxyuridine-5'-triphosphate trisodium
	3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that suppresses DNA-dependent RNA polymerases I and II activity. It competitively obstructs the inclusion of UTP into RNA, demonstrat...
T80760	XSJ2-46		Influenza Virus
	XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA polymerases (RdRp), with an IC50 of 8.78 μM [1].		Influenza Virus
T38297	Ribavirin-13C5	Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to a...