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Juglone

Catalog No. T4010 CAS 481-39-0

Synonyms: 5-Hydroxy-1,4-naphthoquinone, Regianin

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

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Juglone, CAS 481-39-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	5-Hydroxy-1,4-naphthoquinone, Regianin
Molecular Weight	174.15
Formula	C10H6O3
CAS No.	481-39-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15 mg/mL

Ethanol: 15 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hennig L, et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60. 2. Chao SH, et al. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res. 2001 Feb 1;29(3):767-73. 3. Reese S, et al. The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Juglone 481-39-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Antibacterial DNA/RNA Synthesis antimicrobial Pigment inhibit Bacterial Inhibitor 5-Hydroxy-1,4-naphthoquinone Yellow black Regianin walnut inhibitor

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