Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
Description | Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms. |
Synonyms | 5-Hydroxy-1,4-naphthoquinone, Regianin |
Molecular Weight | 174.15 |
Formula | C10H6O3 |
CAS No. | 481-39-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 15 mg/mL
Ethanol: 15 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Juglone 481-39-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Antibacterial DNA/RNA Synthesis antimicrobial Pigment inhibit Bacterial Inhibitor 5-Hydroxy-1,4-naphthoquinone Yellow black Regianin walnut inhibitor