podophyllotoxin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1121	Podofilox	Podophyllotoxin,(+)-Shikonin	Microtubule Associated , Topoisomerase
	Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...		Microtubule Associated , Topoisomerase
TN4813	Podophyllotoxin 4-O-glucoside		Others
	Podophyllotoxin 4-O-glucoside is a natural product of Dysosma, Berberidaceae. The catalog number is TN4813 and the CAS number is 16481-54-2. Podophyllotoxin 4-O-glucoside can be used as a reference standard.		Others
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
TN2356	Tetradehydropodophyllotoxin	Dehydropodophyllotoxin	Others , Antifungal
	Tetradehydropodophyllotoxin (Dehydropodophyllotoxin) has anti-tumor activity.		Others , Antifungal
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
T2937	4'-Demethylepipodophyllotoxin	4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin	Microtubule Associated
	4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.		Microtubule Associated
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T2S0029	4'-Demethylpodophyllotoxin		Others
	4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.		Others
T83321	4-Demethyldeoxypodophyllotoxin		Chk
	4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.		Chk
TN1357	Acetylepipodophyllotoxin		Others
	Acetylepipodophyllotoxin has insecticidal activity.		Others
T83322	4'-Demethyldehydropodophyllotoxin
	4'-Demethyldehydropodophyllotoxin, an aryltetralin lignan derived from the leaves of Podophyllum hexandrum, exhibits cytotoxic and antitumor activity [1].
T1523	Teniposide	NSC 122819,VM26	Topoisomerase
	Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.		Topoisomerase
T81462	Picropodophyllin-β-D-glucoside
	Picropodophyllin-β-D-glucoside (compound 3), a podophyllotoxin glucoside, has been isolated from Chinese medicinal plants [1].
T83001	Antitumor agent-67
	Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin,...
T79708	SSE1806
	SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and antiproliferative properties. It demonstrates a GI50 for inhibiting canc...