pkm2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4170	PKM2-IN-1	PKM2 inhibitor,compound 3k	PKM
	PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.		PKM
T67900	PKM2 inhibitor G		PKM
	PKM2 inhibitor G is a inhibitor of pyruvate kinase.		PKM
T39984	PKM2-IN-3	PKM2-IN-3
	PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC 50 value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect.
T62758	PKM2 activator 2		PKM
	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...		PKM
T61504	PKM2 activator 3
	PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is part...
T81446	PKM2 activator 6
	Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM, respectively. It promotes apoptosis in colorectal cells while suppress...
T72692	PKM2 activator 4
	PKM2 Activator 4, a chemical compound, functions as an activator of PKM2 with an activation concentration (AC 50) ranging from 1 to 10 μM. It is primarily utilized in cancer research.
T79636	PKM2-IN-4
	Compound 5C, referred to as Pkm2-in-4, is a selective PKM2 inhibitor (IC50 = 0.35 µM) that modulates pyruvate-dependent respiration and promotes mitochondrial H2O2 production rate and electron transport system coupling [...
T72693	PKM2 activator 5		PKM
	PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.		PKM
T71867	PKM2 inhibitor 2825-0090
	PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo.
T74814	PKM2/PDK1-IN-1
	PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS producti...
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
T3376	Cynaroside	Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside	Others , Influenza Virus , DNA/RNA Synthesis
	Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.		Others , Influenza Virus , DNA/RNA Synthesis
T1125	Shikonin	NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid	TNF , NF-κB , Chloride channel , HIV Protease , PKM
	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.		TNF , NF-κB , Chloride channel , HIV Protease , PKM
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
T7214	TEPP-46	ML265	PKM
	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .		PKM
T60102L	Dimethylaminomicheliolide HCl		PKM
	Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations.		PKM
T15362	FX-11	LDHA Inhibitor FX11	Dehydrogenase
	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...		Dehydrogenase
T68986	ZINC08383544
	ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.
T70665	PF-06284674
	PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.