Search Result

Search Results for " pcs "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16443	PCS1055 dihydrochloride		Others
	PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM f...		Others
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T72025	PCSK9-IN-10		Serine/threonin kinase
	PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Li...		Serine/threonin kinase
T75147	PCSK9-IN-18
	PCSK9-IN-18 (compound 188) is a potent PCSK9 inhibitor with a K D value of <200 nM [1] .
T73008	PCSK9-IN-13
	PCSK9-IN-13 is a potent inhibitor of PCSK9, effectively preventing the binding of PCSK9 to low-density lipoprotein (LDL) receptors through its mechanism of action. It exhibits this inhibitory activity with an IC 50 value...
T13813	PCSK9 ligand 1		Others
	PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).		Others
T39685	PCSK9 degrader 1
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T79053	PCSK9-IN-17
	PCSK9-IN-17 is a PCSK9 inhibitor utilized in the research of cholesterol metabolism.
T79052	PCSK9-IN-16
	PCSK9-IN-16, holds potential for research into hypercholesterolemia and other cardiovascular diseases [1].
T79239	PCSK9-IN-19
	PCSK9-IN-19 (Compound 1), a PCSK9 inhibitor, is utilized in researching the treatment of high LDL-cholesterol levels and the prevention of coronary artery disease [1].
T79030	PCSK9-IN-14
	PCSK9-IN-14, also known as compound Ia-8, is a potent inhibitor of PCSK9 [1].
T60541	PCSK9 modulator-2
	PCSK9 modulator-2 (Compound 1) is a potent PCSK9 modulator (EC 50 = 202 nM) that has the potential to be used in hyperlipidemia research. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently validated ther...
T39528	PCSK9-IN-2	PCSK9-IN-2
	PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T60646	PCSK9 modulator-3
	PCSK9 modulator-3 (Compound 13) is a potent PCSK9 modulator with an EC 50 value of 2.46 nM that has the potential in the hyperlipidemia research. PCSK9 is a recently proved target for lowering low-density lipoprotein cho...
T79051	PCSK9-IN-15
	PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, K D <200 nM) that plays a crucial role in cholesterol metabolism by regulating blood levels of low-density lipoprotein ch...
T60764	PCSK9 modulator-4
	PCSK9 modulator-4 (Compound 21) can be used in hyperlipidemia research that is a potent PCSK9 modulator (EC 50 = 0.15 nM). PCSK9 is a lowering low-density lipoprotein cholesterol (LDL-C) target that is recently validated...
T29890	AlPcS4	Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine
	AlPcS4 , also known as aluminum phthalocyanine tetrasulfonate Chloroaluminum tetrasulfophthalocyanine; or AlS4Pc, AlPcS4(a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer...
T81535	PCSK9-IN-20
	PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor exhibiting an IC50 value of 3.96 µM, shown to reduce PCSK9 and enhance LDLR protein levels in vitro [1].
T74167	PCSK9-IN-3
	PCSK9-IN-3 is a next-generation tricyclic peptide inhibitor of PCSK9, characterized by its novel structure, high potency, and oral bioavailability.

Compounds

PCS1055 dihydrochloride

Target: Serine/threonin kinase

Synonym: PCSK9-IN-2

Synonym: Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine

Cat No.	Product Name	Targets
T75545	PCSK9-IN-9
	PCSK9-IN-9, a natural isocoumarin, inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression, demonstrating specificity by inhibiting PCSK9 with an IC50 value of 11.9 μM [1].
T5692	Pyrroloquinoline quinone	Others , Endogenous Metabolite
	Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,	Others , Endogenous Metabolite

Natural Products

Pyrroloquinoline quinone

T5692

Synonym:

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00723	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His)	Human	HEK293 Cells
	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109.2 kDa and the accession number is Q9P232.
TMPY-00722	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc)	Human	HEK293 Cells
	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 134.5 kDa and the accession number is Q9P232.
TMPY-00408	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-05131	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His)	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPY-05114	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.
TMPJ-00369	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q...
TMPY-01635	PCSK1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the...
TMPY-05217	PCSK9 Protein, Mouse, Recombinant (mFc)	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01245	PCSK9 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-05218	PCSK9 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPY-05270	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05199	PCSK9 Protein, Human, Recombinant (D374Y, mFc)	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPK-00483	PCSK9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injec...
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His)	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in ...
TMPJ-00368	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPY-01565	PCSK9 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6.
TMPY-00995	PCSK9 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293 Cells
	PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666.