nrf2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39719	Nrf2 activator-1	Nrf2 activator-1	Nrf2
	Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2).Nrf2 activator-1 can be used to study COPD and other respiratory diseases including asthma, acute lung injury (ALI), acute respiratory distress synd...		Nrf2
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T78650	Nrf2 activator-3		Antioxidant , Nrf2
	Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases.		Antioxidant , Nrf2
T24546	Nrf2-Activator-12G	Nrf2 Activator IV,Nrf2 Activator-IV
	Nrf2-Activator-12G is a potent Nrf-2 activator.
T39514	Keap1-Nrf2-IN-3	Keap1-Nrf2-IN-3
	Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.
T11752	Keap1-Nrf2-IN-1	Keap1–Nrf2-IN-1	Src
	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear fa...		Src
T63016	Nrf2 activator-4		Reactive Oxygen Species , Nrf2
	Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.		Reactive Oxygen Species , Nrf2
T72697	Nrf2 activator-6
	Nrf2 Activator-6, a tetrahydroisoquinoline compound, functions as an Nrf2 activator, demonstrating potency with an IC50 value of 5 nM in inhibiting the Kelch domain-Nrf2 interaction.
T79702	Nrf2 activator-9
	Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular...
T80522	Keap1-Nrf2 probe
	Keap1-Nrf2 probe [1] is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2).
T79484	Nrf2 activator-8
	Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably...
T72760	Keap1-Nrf2-IN-6
	Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM and a dissociation constant (Kd) of 68 nM.
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...
T78696	Nrf2 activator-7
	Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.
T61688	Nrf2 activator-2
	Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 acti...
T78841	Nrf2-IN-3
	Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, ...
T63364	Nrf2 activator-5
	Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.
T72417	AChE/Nrf2 modulator 1
	AChE/Nrf2 modulator 1, an orally active compound, serves as a modulator of acetylcholinesterase (AChE) and nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits Nrf2 inductive activity alongside inhibitory effe...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI) with an IC50 value of 0.575 µM. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1),...
T72706	Keap1-Nrf2-IN-13
	Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen...