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Keap1-Nrf2-IN-1

Catalog No. T11752 CAS 2232112-72-8

Synonyms: Keap1–Nrf2-IN-1

Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.

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Keap1-Nrf2-IN-1, CAS 2232112-72-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,430.00
50 mg	6-8 weeks	$ 1,860.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.
Targets&IC50	Keap1 protein:43 nM

Synonyms	Keap1–Nrf2-IN-1
Molecular Weight	484.52
Formula	C24H24N2O7S
CAS No.	2232112-72-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

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Keywords

Keap1-Nrf2-IN-1 2232112-72-8 Angiogenesis Tyrosine Kinase/Adaptors Src Keap1–Nrf2-IN-1 Keap1 Nrf2 IN 1 Keap1Nrf2IN1 Keap-1-Nrf2-IN-1 inhibitor inhibit

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