neuropsychiatric — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12998	SR10067		Others , Autophagy
	SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbα/β(IC50 of 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively),has anxiolytic activity.		Others , Autophagy
T2141	Mecamylamine hydrochloride	Inversine,Mevasin	AChR
	Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension.		AChR
T34374	RO5203648 HCl	RO5203648,RO-5203648,RO 5203648	Others
	RO5203648 HCl is a partial agonist of trace amine-related receptor 1 (TAAR1) with antipsychotic and antidepressant-like activities. RO5203648 HCl can be used in studies about neuropsychiatric therapeutics.		Others
T22882	JP1302		Adrenergic Receptor
	JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been u...		Adrenergic Receptor
T60060	ACSS2-IN-2	MTB-9655	Fatty Acid Synthase
	ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis...		Fatty Acid Synthase
T14782	Brilaroxazine	RP5063	Dopamine Receptor , 5-HT Receptor
	Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...		Dopamine Receptor , 5-HT Receptor
T13322	VU6005806	AZN-00016130	Others
	VU6005806 is a potent positive allosteric modulator (PAM) of muscarinic acetylcholine receptor subtype 4 (M4) (EC50s: 94 nM, 28 nM, 87 nM, and 68 nM for human, rat, dog, and cyno M4, respectively), and used in the study ...		Others
T79430	μ opioid receptor agonist 3		Opioid Receptor
	Compound 20, identified as μ opioid receptor agonist 3, is a potent µOR agonist that exhibits an EC50 value of 0.87 nM. It holds promise for research into pain management and neuropsychiatric disorders [1].		Opioid Receptor
T69019	Mecamylamine
	Mecamylamine, an orally active, nonselective, noncompetitive antagonist of nAChR (nicotinic acetylcholine receptors), exhibits ganglionic blockade capabilities and can cross the blood-brain barrier. Its applications span...
T62133	TRPC5 modulator-1
	TRPC5 modulator-1 (Compound 9) is a TRPC5 modulator (IC50<1 nM) that can be used to study neuropsychiatric disorders.
T78078	GPR52 receptor modulator 1		Others
	GPR52 receptor modulator 1, a compound delineated as per Procedure 1, is a modulator of the GPR52 receptor, offering research potential in the investigation of neuropsychiatric diseases [1].		Others
T69473	Pifoxime
	Pifoxime, a non-steroidal anti-inflammatory agent (NSAID) and COX-1/2 inhibitor, exhibits anti-inflammatory properties, making it useful in neuropsychiatric research.
T39771	NAChR agonist CMPI hydrochloride
	CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAC...
T80421	CSD-CH2(1,8)-NH2		Opioid Receptor
	CSD-CH2(1,8)-NH2 is a selective and competitive kappa-opioid receptor (KOR) antagonist with a K i of 6.8 nM. It inhibits calcium mobilization in dorsal root ganglion (DRG) neurons and antagonizes the antinociceptive effe...		Opioid Receptor
T35560	SAR502250
	SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM. It exhibits antidepressant-like activity and is being researched for potential...