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JP1302

Name: JP1302
Brand: TargetMol
SKU: T22882
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22882Cas No. 80259-18-3

JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been used in the study of neuropsychiatric disorders, acute renal failure, and renal injury.

JP1302

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Purity: 99.96%

Catalog No. T22882Cas No. 80259-18-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$251	In Stock	In Stock
50 mg	$437	In Stock	In Stock
100 mg	$646	-	In Stock
500 mg	$1,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.96%

Appearance:Solid

Color:Red

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been used in the study of neuropsychiatric disorders, acute renal failure, and renal injury.
Targets&IC50	α2D-adrenoceptor (rodent):1700±200 nM (Ki), α2B-adrenoceptor (human):1470±130 nM (Ki), α2A-adrenoceptor (human):3150±50 nM (Ki), α2C-adrenoceptor (human):28±2 nM (Ki)
In vitro	JP1302 exhibits approximately a 100-fold greater affinity compared to α2A or α2B.[1]
In vivo	JP1302 (5 μmol/kg; once; Sprague-Dawley rats) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine, and similar results are found in Wistar rats.[1] JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine.[1] JP1302 (3 mg/kg; IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion; once; Male Sprague Dawley rats ) significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, and histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.[3]

Chemical Properties

Molecular Weight	368.47
Formula	C₂₄H₂₄N₄
Cas No.	80259-18-3
Smiles	N(C=1C2=C(N=C3C1C=CC=C3)C=CC=C2)C4=CC=C(C=C4)N5CCN(C)CC5
Relative Density.	1.227g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.85 mg/mL (100.01 mM), Sonication is recommended.

H2O: insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7139 mL	13.5696 mL	27.1393 mL	135.6963 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL	27.1393 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL	13.5696 mL
20 mM	0.1357 mL	0.6785 mL	1.3570 mL	6.7848 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7139 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	1.3570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc