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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40870 | Leukotriene E4 | LTE4 | Endogenous Metabolite |
Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detec... | |||
T14326 | AS-35 | Others | |
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergi... | |||
T37494 | 11-trans Leukotriene E4 | 11-trans Leukotriene E4 | |
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum. | |||
T38062 | N-acetyl Leukotriene E4 | N-acetyl Leukotriene E4 | |
N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstri... | |||
T27877 | LY 163443 | LY163443,LY-163443 | |
LY 163443 is an dual receptor antagonist of LTD4 and LTE4. | |||
T27904 | LY 245769 | LY-245769,LY245769 | |
LY 245769 is an inhibitor of leukotriene E4 (LTE4). | |||
T0694 | Pranlukast | ONO-1078 | Leukotriene Receptor , IL Receptor , Others , TNF , NF-κB , LTR |
Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered aller... | |||
T38129 | Leukotriene F4 | LTF4 | |
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contrac... | |||
T37262 | 14,15-Leukotriene E4 | 14,15-Leukotriene E4 | |
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metaboli... | |||
T63291 | Pranlukast hemihydrate | ||
Pranlukast hemihydrate is a selective, potent and competitive antagonist of leukotriene.Pranlukast inhibits [3H]LTE4 (Ki: 0.63±0.11 nM), [3H]LTD4 (Ki: 0.99±0.19 nM) and [3H]LTC4 (Ki: 5640 ±680 nM) were bound to the lung ... | |||
T16739 | RG-12525 | NID 525 | Leukotriene Receptor , PPAR |
RG-12525(NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM... | |||
T37980 | N-methyl Leukotriene C4 | N-methyl Leukotriene C4 | |
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione t... | |||
T15647 | Tipelukast | MN 001,KCA 757 | Leukotriene Receptor |
Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma. |