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Pranlukast

Catalog No. T0694 CAS 103177-37-3

Synonyms: ONO-1078

Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

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Pranlukast, CAS 103177-37-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 50.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 90.00
200 mg	In stock	$ 129.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.85%

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Description	Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Targets&IC50	LTC4:5640 nM (Ki), LTD4:0.99 nM (Ki), LTE4:0.63 nM (Ki)
In vitro	Pranlukast significantly reduces the volume of injury in the cortical and hippocampal CA1 regions of the ischemic hemisphere in mice and increases neuronal density. Additionally, Pranlukast markedly thins the scar wall in the ischemic hemisphere of mice.
In vivo	In sensitized guinea pig tracheas, 5 mM of either Pranlukast or Zafirlukast significantly inhibited ovalbumin-induced secretion by 70% and 65%, respectively. These compounds also markedly inhibited 35SO4 release triggered by 10 mM LTD4 in a concentration-dependent manner, with Pranlukast showing a peak inhibition of 83% and Zafirlukast 78% at 10 mM, having IC50 values of 0.3 mM and 0.6 mM, respectively. Pranlukast suppressed the activation of NF-κB in 1.3% DMSO-differentiated U-937 and Jurkat cells, with inhibition rates of 40% and 30%; it also demonstrated a dose-dependent inhibition of NF-κB activation in combination with MK-571. Pranlukast and MK-571 diminished LPS-induced IL-6 production in PBMCs by approximately 65% and 15%. Additionally, Pranlukast inhibited the activation of NF-κB induced by phorbol 12-myristate 13-acetate and significantly reduced LPS-induced MUC2 mRNA expression in NCI-H292 cells, as determined by reverse transcription-polymerase chain reaction. Pranlukast also suppressed the expression of the MUC2 gene in LPS-stimulated HM3-MUC2 cells.

Synonyms	ONO-1078
Molecular Weight	481.5
Formula	C27H23N5O4
CAS No.	103177-37-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.1 mg/mL (50 mM)

References and Literature

1. Ichiyama T, et al. Clin Exp Allergy,2003, 33(6), 802-807. 2. Liu YC, et al. Br J Pharmacol,1998, 124(3), 563-571. 3. Ishinaga H, et al. Pharmacology,2005, 73(2), 89-96. 4. Yu GL, et al. Brain Res. 2005 Aug 16;1053(1-2):116-25. 5. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches[J]. RSC Advances. 2018 Jan 8(10): 5286-5297.

Citations

1. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches. RSC Advances. 2018 Jan 8(10): 5286-5297. 2. Chen X, Li C, Wang Z, et al.Computational screening of biomarkers and potential drugs for arthrofibrosis based on combination of sequencing and large nature language model.Journal of Orthopaedic Translation.2024, 44: 102-113.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library Pyroptosis Compound Library NO PAINS Compound Library Immuno-Oncology Compound Library Anti-Aging Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Pranlukast 103177-37-3 Apoptosis GPCR/G Protein Immunology/Inflammation NF-Κb Others IL Receptor Leukotriene Receptor NF-κB TNF LTR Inhibitor ONO-1078 inhibit ONO 1078 ONO1078 inhibitor

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