lsd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81913	LSD
	LSD-phthalocyanine is a conjugated compound utilized in photoimmunology research [1].
T31361	Deethyl-LSD	LAE 32,Lysergic acid ethylamide,LAE-32,N-Ethyllysergamide,LAE32
	Deethyl-LSD is reported to have some LSD-like effects but is weaker and shorter-lasting, with an active dose reported to be between 0.5 and 1.5 milligrams.
T67871	LSD1-IN-24		Histone Demethylase , PD-1/PD-L1
	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.		Histone Demethylase , PD-1/PD-L1
T2315	GSK-LSD1 dihydrochloride	GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl	Histone Demethylase
	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ...		Histone Demethylase
T11880	LSD1-IN-5		Histone Demethylase
	LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM.		Histone Demethylase
T11881	LSD1-IN-6		Histone Demethylase
	LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM.		Histone Demethylase
T36625	LSD1/HDAC6-IN-1	LSD1/HDAC6-IN-1
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ...
T63140	LSD1-IN-20		Histone Demethylase
	Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, w...		Histone Demethylase
T83966	LSD1-IN-30		Histone Demethylase
	LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia.		Histone Demethylase
T77635	LSD1-IN-27		Histone Demethylase , PD-1/PD-L1
	LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited the expression of PD-L1 in BGC-823 and MFC cells.LSD1-IN-27 p...		Histone Demethylase , PD-1/PD-L1
T60360	LSD1/2-IN-3
	LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 ( LSD1 ) with a Ki value of 11 nM rather than 7 μM for LSD2. There is aberrant expression of LSD1 in tumor stem cells, LSD1/2-IN-1 inhibits LSD1 cell ...
T60941	LSD1-IN-15
	LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor that inhibit LSD1-CoREST, MAO-A and MAO-B with IC 50 values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 shows cell growth arrest in LNCaP cells of prostate ...
T62674	LSD1-IN-21
	LSD1-IN-21 is a potent, blood-brain barrier permeable LSD1 (lysine specific demethylase-1) inhibitor (IC50: 0.956 μM).LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α and exhibits good anti-cancer and...
T60362	LSD1-IN-22
	LSD1-IN-22 is a potent inhibitor of Lysine-specific demethylase 1 ( LSD1 ) with a K i value of 98 nM. LSD1-IN-22 has anti-proliferative activity against certain cancer cells [1].
T60361	LSD1/2-IN-4
	LSD1/2-IN-4, a derivative of PCPA, functions as an inhibitor for both lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2), demonstrating K i values of 0.11 μM and 130 μM against LSD1 and LSD2, r...
T62679	LSD1-IN-13 hydrochloride
	LSD1-IN-13 hydrochloride (compound 7e) is an orally active inhibitor of LSD1 (IC50: 24.43 nM). hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines.
T62818	LSD1/ER-IN-1
	LSD1/ER-IN-1 (compound 11g) is a potent inhibitor of ER and LSD1 that acts on LSD1 (IC50: 1.55 μM). LSD1/ER-IN-1 showed good anti-proliferative effect on MCF-7 breast cancer cells (IC50: 8.79 μM).
T74855	LSD1-IN-25		Histone Demethylase
	LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1].		Histone Demethylase
T82254	GSK-LSD1		Histone Demethylase
	GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (...		Histone Demethylase
T78888	LSD1-UM-109		Histone Demethylase
	LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM. This compound exhibits strong antiproliferative activity, inhibiting cell growth with IC50 values of 0.6 nM in the MV4;11 ...		Histone Demethylase
T74858	LSD1-IN-26
	LSD1-IN-26 (compound 12u), a potent LSD1 inhibitor, exhibits an IC50 of 25.3 nM. It also demonstrates inhibition of MAO-A (IC50 = 1234.57 nM) and MAO-B (IC50 = 3819.27 nM), significantly inducing apoptosis in MGC-803 cel...
T60381	LSD1-IN-12
	LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively [1].
T63920	LSD1-IN-19
	LSD1-IN-19 (compound 29) is a selective, potent, non-covalent inhibitor of LSD1 (Ki: 0.108 μM, KD: 0.068 μM). The 72h IC50 values were 0.17 and 0.40 μM, respectively.
T61021	LSD1-IN-16
	LSD1-IN-16 (compound 4b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B with IC50 values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 exhibits cell growth arrest in prostate cancer LN...
T61022	LSD1-IN-17
	LSD1-IN-17 (compound 5b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B, with IC 50 values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 exhibits cell growth arrest in prostate cancer ...
T63716	LSD1-IN-18
	LSD1-IN-18 is a potent, non-covalent, selective inhibitor of LSD1 (Ki:0.156 μM; KD: 0.075 μM).LSD1-IN-18 exhibited anti-proliferative effects in THP-1 leukemia cells and MDA-MB-231 breast cancer cells with IC50 (72 h) of...
T61405	LSD1-IN-14
	LSD1-IN-14, a powerful and specific inhibitor of LSD1 (with an IC50 value of 0.89 μM), effectively suppresses the growth of A549 and THP-1 cells and promotes the apoptosis of tumor cells [1].
T62099	LSD1-IN-13
	LSD1-IN-13 (compound 7e) is an orally active LSD1 inhibitor (IC50: 24.43 nM) that also activates CD86 expression (EC50: 470 nM).LSD1-IN-13 induces differentiation of AML (acute myeloid leukaemia) cell lines.
T32906	LSZ
	LSZ is an analog of LSD.
T36627	Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
	Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used a...

Compounds

LSD

T81913

Synonym: LAE 32,Lysergic acid ethylamide,LAE-32,N-Ethyllysergamide,LAE32

Target: Histone Demethylase, PD-1/PD-L1

GSK-LSD1 dihydrochloride

T2315

Synonym: GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl

Target: Histone Demethylase

LSD1-IN-5

T11880

Synonym:

Target: Histone Demethylase

LSD1-IN-6

T11881

Synonym:

Target: Histone Demethylase

LSD1/HDAC6-IN-1

T36625

Synonym: LSD1/HDAC6-IN-1

Target: Histone Demethylase

LSD1-IN-30

T83966

Synonym:

Target: Histone Demethylase

LSD1-IN-27

T77635

Synonym:

Target: Histone Demethylase, PD-1/PD-L1

LSD1-IN-13 hydrochloride

Target: Histone Demethylase

GSK-LSD1

T82254

Synonym:

Target: Histone Demethylase

LSD1-UM-109

T78888

Synonym:

Target: Histone Demethylase

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)

T36627

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01212	DNASE1L3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01213	DNASE1L3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01214	DNASE1L3 Protein, Human, Recombinant	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPY-03056	LSD1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 ...
TMPH-03560	lsdA Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	lsdA Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.1 kDa and the accession number is Q6GA85.
TMPH-03561	lsdB Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays i...