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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9920 | Evolocumab | Others | |
Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9). | |||
T9276 | SBC-115337 | Others , Serine/threonin kinase | |
SBC-115337 is a PCSK9 inhibitor. | |||
T67776 | PCSK9-IN-11 | Others | |
PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l... | |||
T72025 | PCSK9-IN-10 | Serine/threonin kinase | |
PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Li... | |||
T74577 | Milpocitide | ||
Milpocitide, a (293-333)-peptide fragment of the human low-density lipoprotein receptor (LDLR), specifically corresponds to the EGF-like domain 1 [1]. | |||
T15561 | Imanixil | HOE-402(free base) | Others |
Imanixil is an inducer of the LDL receptor (LDLR) and it is also a potent cholesterol-lowering compound. It also inhibits very low density-lipoprotein (VLDL) production and consequently decreases atherosclerosis developm... | |||
T81535 | PCSK9-IN-20 | ||
PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor exhibiting an IC50 value of 3.96 µM, shown to reduce PCSK9 and enhance LDLR protein levels in vitro [1]. | |||
T39528 | PCSK9-IN-2 | PCSK9-IN-2 | |
PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM. | |||
T77014 | Frovocimab | ||
Frovocimab (LY 3015014), a humanized IgG4 monoclonal antibody (mAb), acts by neutralizing PCSK9. This mechanism effectively prevents PCSK9 from binding to the LDL receptor (LDLR) while allowing for the normal proteolytic... | |||
T78718 | Dim16 | ||
Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interaction with an IC50 of 0.8 nM, leading to an enhanced LDL uptake in He... | |||
T78806 | PPARδ agonist 9 | PPAR | |
PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic development in the LDLr-KO model with an inhibition rate of... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5S0053 | Coptisine | Coptisin | Indoleamine 2,3-Dioxygenase (IDO) |
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00989 | LDLR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5. | |||
TMPK-00402 | LDLR Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe... | |||
TMPK-01297 | LDLR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe... | |||
TMPJ-00394 | LDLR Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repe... | |||
TMPY-01014 | LDLR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
LDLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951. | |||
TMPY-05323 | LDLR Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
LDLR Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 111.2 kDa and the accession number is A0A024R7D5. | |||
TMPY-05348 | LDLR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
LDLR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951. | |||
TMPY-05499 | LDLR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
LDLR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5. | |||
TMPY-05809 | LDLR Protein, Human, Recombinant (193D/A, His) | Human | HEK293 Cells |
LDLR Protein, Human, Recombinant (193D/A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.19 kDa and the accession number is A0A024R7D5. | |||
TMPY-01085 | VLDLR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A... | |||
TMPK-00928 | VLDLR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
VLDLR cerebellar hypoplasia (VLDLR-CH) is characterized by non-progressive congenital ataxia that is predominantly truncal and results in delayed ambulation, moderate-to-profound intellectual disability, dysarthria, stra... | |||
TMPY-00383 | LDLRAD3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LDLRAD3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is Q86YD5-1. | |||
TMPY-01451 | MESDC2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a m... | |||
TMPJ-00443 | PCSK9 Protein, Macaca nemestrina, Recombinant (His) | Macaca nemestrina | HEK293 Cells |
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in ... | |||
TMPJ-01412 | LRP-12 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c... | |||
TMPY-02604 | UBE2D4 Protein, Human, Recombinant (His) | Human | E. coli |
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed... |