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Imanixil

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Catalog No. T15561Cas No. 75689-93-9
Alias HOE-402 free base

Imanixil (HOE-402 free base) is an LDL receptor (LDLR) inducer, a hypolipidemic and hypocholesterolemic compound with antiatherogenic activity that inhibits the production of very low-density lipoproteins (VLDLs).Imanixil acts by stimulating the LDL receptor pathway.

Imanixil

Imanixil

😃Good
Catalog No. T15561Alias HOE-402 free baseCas No. 75689-93-9
Imanixil (HOE-402 free base) is an LDL receptor (LDLR) inducer, a hypolipidemic and hypocholesterolemic compound with antiatherogenic activity that inhibits the production of very low-density lipoproteins (VLDLs).Imanixil acts by stimulating the LDL receptor pathway.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$179In StockIn Stock
5 mg$443In StockIn Stock
10 mg$653In StockIn Stock
25 mg$987In StockIn Stock
50 mg$1,390In StockIn Stock
100 mg$1,880-In Stock
1 mL x 10 mM (in DMSO)$453In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:>99.99%
Appearance:Solid
Color:White
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COA FNMR HNMR LCMS

Product Introduction

Bioactivity
Description
Imanixil (HOE-402 free base) is an LDL receptor (LDLR) inducer, a hypolipidemic and hypocholesterolemic compound with antiatherogenic activity that inhibits the production of very low-density lipoproteins (VLDLs).Imanixil acts by stimulating the LDL receptor pathway.
In vivo
Treatment with 0.05% (w/w) Imanixil (HOE-402(free base)) resulted in a maximal reduction of serum cholesterol levels in wild-type LDLR+/0 and LDLR0/0 mice by 53%, 56%, and 73%, respectively (P<0.05), and a reduction of very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) cholesterol levels increased. (LDL) cholesterol levels, and elevated high-density lipoprotein (HDL) cholesterol levels, Imanixil (HOE-402 (free base)) inhibits the production of VLDL, thereby attenuating the development of atherosclerosis. [2]
SynonymsHOE-402 free base
Chemical Properties
Molecular Weight394.35
FormulaC17H17F3N6O2
Cas No.75689-93-9
SmilesCC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (202.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5358 mL12.6791 mL25.3582 mL126.7909 mL
5 mM0.5072 mL2.5358 mL5.0716 mL25.3582 mL
10 mM0.2536 mL1.2679 mL2.5358 mL12.6791 mL
20 mM0.1268 mL0.6340 mL1.2679 mL6.3395 mL
50 mM0.0507 mL0.2536 mL0.5072 mL2.5358 mL
100 mM0.0254 mL0.1268 mL0.2536 mL1.2679 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VLDLImanixilHOE-402(free base)
Related Tags: buy Imanixil | purchase Imanixil | Imanixil cost | order Imanixil | Imanixil chemical structure | Imanixil in vivo | Imanixil formula | Imanixil molecular weight
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