l1210 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1488	Procarbazine hydrochloride	NSC-77213 HCl,Procarbazine HCl	DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis
T4745	4-Carboxyquinoline	QUINOLINE-4-CARBOXYLIC ACID,4-Quinolinecarboxylic acid	Others , Endogenous Metabolite
	4-Carboxyquinoline (4-Quinolinecarboxylic acid) showed anti-tumor activity against L1210 leukemia and B16 melanoma.		Others , Endogenous Metabolite
TQ0213	Bruceantin	(-)-Bruceantin,NCI165563,NSC165563	Others
	Bruceantin (NSC-165563) is a natural product isolated from Brucea antidysenterica. Bruceantin has antitumor activity against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.		Others
T6632	Raltitrexed	ZD1694,D1694,ICI-D1694,Tomudex	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T8188	Podophyllotoxone		Others , Microtubule Associated
	Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.		Others , Microtubule Associated
TN2496	1,4-Anthraquinone		Others
	1,4-Anthraquinone is an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar ...		Others
T3S1955	7-Ethylcamptothecin		Others
	1. 7-Ethylcamptothecin has the superior antitumor activity than CPT. (a). 7-Ethylcamptothecin has a stronger growth-inhibiting activity against tumor cells. (b). 7-Ethylcamptothecin remains in the intestinal tract for a ...		Others
T1349	5-Fluorouridine		Others , DNA/RNA Synthesis
	5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compound...		Others , DNA/RNA Synthesis
T24990	8-Deazafolic acid	NSC-173522,NSC173522,NSC 173522
	8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice.
T69199	Homopteroic Acid
	Homopteroic Acid is an intermediate in the synthesis of Homofolic Acid which inhibits the growth of L1210 mouse leukemia cells when intracellular folates are acquired via the high-affinity folate binding protein.
T69172	Acetomycin
	Acetomycin is a γ-lactone microbial metabolite originally isolated from S. ramulosus that has anticancer activity. It inhibits proliferation of HCT-8 human colon and L1210 mouse leukemia cancer cells.
TN3075	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone		ATPase
	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell.		ATPase
TN4944	Santamarine		Caspase
	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity agai...		Caspase
TMA2418	1-Methoxyphaseollidin		PAFR , Antifection
	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity agains...		PAFR , Antifection
T75453	11-epi-Chaetomugilin I
	11-epi-Chaetomugilin I, a metabolite identified in Chaetomium globosum, demonstrates notable cytotoxic activity against several cell lines, including the murine P388 and L1210 leukemia cell lines, the human HL-60 leukemi...
TN6069	Thalidezine
	Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death, it can inhibit the growth of mouse L1210 cells in vitro. Thalidezine possesses antimicrobial...
T69057	Elliptinium acetate	NSC 264137,Celiptium,NSC 264137 ; Celiptium
	Elliptinium acetate (NSC 264137), a DNA intercalating agent, exhibits high cytotoxicity towards L1210 cells and forms covalent bonds with nucleic acids from these cells. It holds potential in cancer research, especially ...
T68952	NU1064
	NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration...
T70304	CI-898 HCl
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1...
T83862	Bactobolin A hydrochloride	BN-183B
	Bactobolin A, a microbial metabolite initially derived from Pseudomonas, exhibits both antibiotic and anticancer properties. It demonstrates activity against various bacteria including S. aureus, S. epidermidis, S. faeca...