jak — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11710	JAK-IN-5		JAK
	JAK-IN-5 is a JAK inhibitor.		JAK
T13571	JAK-IN-10		JAK
	JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.		JAK
T12549	JAK-IN-11	R-348	JAK
	JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.		JAK
T27650	JAK3i	JAK-3i,JAK 3i	JAK
	JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cel...		JAK
T61494	JAK-IN-21		Tyrosine Kinases , JAK
	JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.		Tyrosine Kinases , JAK
T78607	JAK-STAT-IN-1		JAK , STAT
	JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.		JAK , STAT
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T11710L	JAK-IN-5 hydrochloride	JAK-IN-5 hydrochloride(2096999-92-5 Free base)	JAK
	JAK-IN-5 hydrochloride is a JAK inhibitor [1].		JAK
T39400	JAK-IN-15
	JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).
T9764	JAK-IN-14
	JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC 50 of <5 μM. JAK-IN-14 is more than 8-fold selective for JAK1 than JAK2 and JAK3 [1].
T11705	JAK-IN-4		Others
	JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.		Others
T11704	JAK-IN-3		CCR
	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.		CCR
T11703	JAK-IN-1		Others
	JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.		Others
T38436	JAK-2/3-IN-1
	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
T2460	JAK 3 inhibitor IV	ZM 39923 hydrochloride,Jak3 inhibitor IV	EGFR , Others , JAK
	JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.		EGFR , Others , JAK
T82018	JAK-IN-33		JAK
	JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].		JAK
T73250	JAK-IN-17
	JAK-IN-17 is a potent inhibitor of JAK . JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases.
T63658	JAK-IN-18
	JAK-IN-18 is a potent inhibitor of JAK and can be used to study a variety of diseases, particularly eye, skin and respiratory diseases.
T73330	JAK-IN-24
	JAK-IN-24, a JAK inhibitor, exhibits IC50 values of 0.534 nM and 24 nM in the presence of 4 μM and 1 mM ATP, respectively. Additionally, it effectively inhibits STAT5 phosphorylation induced by PBMC IL-15 with an IC50 of...
T78175	JAK-IN-25		JAK
	JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-1...		JAK