irinotecan — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
T0486	Irinotecan hydrochloride trihydrate	Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate	Topoisomerase , Autophagy
	Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.		Topoisomerase , Autophagy
T0486L	Irinotecan Hydrochloride	Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase , Autophagy
	Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptoth...		Topoisomerase , Autophagy
T70959	Irinotecan Carboxylate Sodium Salt
	Irinotecan Carboxylate Sodium Salt is a DNA topoisomerase inhibitor.
T70957	NMac1
	NMac1is a small molecule phenylbutenoid dimer that has novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells. NMac1 causes significant activation of AMPK by decreasing ATP synthe...
T1703	SN-38	NK012,SN 38	DNA/RNA Synthesis , Topoisomerase , Autophagy
	SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.		DNA/RNA Synthesis , Topoisomerase , Autophagy
T6S1559	Aurantio-obtusin		Others
	1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of ...		Others
T73905	SN-38 glucuronide
	SN-38 glucuronide, an inactive metabolite of Irinotecan, serves as a derivative of this cancer-fighting agent. Irinotecan, known for inhibiting topoisomerase I, is utilized in the research of colon and rectal cancer [1].
T70312	AZ1366
	AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compare...
T12766	RPR121056	APC	AChR
	RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.		AChR
T38962	MC-SN38	MC-SN38
	MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisome...
T38474	CL2-MMT-SN38	CL2-MMT-SN38
	CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.
T81924	LK-44
	Compound 44 (hCES2A-IN-2) is an orally active inhibitor of human carboxylesterase 2 (hCES2A) with an IC50 of 5.02 μM, which ameliorates Irinotecan-induced delayed diarrhea [1].
T31837	FOLFIRI Regimen	FOLFIRI
	FOLFIRI Regimen is a chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used during the treatment of advanced-stage and metastatic colorectal cancer.
T82710	CL2E-SN38
	CL2E-SN-38 is a structurally stable and highly releasable antibody-drug conjugate (ADC) incorporating SN-38, the active metabolite of Irinotecan and a potent Topoisomerase I inhibitor [1] from the camptothecins class.
T95359	Compound F0433-0067
	hiCE inhibitor-1 is a sulfonamide derivative that is a selective human intestinal enzyme ( hiCE ) inhibitor with a K i value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan -induced diarrhoea [1].
T74491	Antitumor agent-61
	Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity, as evidenced by its IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3...
T77837	CL2E-SN38 TFA
	CL2E-SN-38 TFA, a structurally stable and highly releasable antibody drug conjugate (ADC), comprises SN-38, the active metabolite of Irinotecan derived from camptothecins, known for its Topoisomerase I inhibitory activit...
T79263	Antitumor agent-102		Topoisomerase
	Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets colorectal cancer. This agent facilitates elevated levels of free SN3...		Topoisomerase
T35942	AZ 5704
	Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Pot...