Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 36.00 | |
50 mg | In stock | $ 52.00 | |
100 mg | In stock | $ 72.00 | |
200 mg | In stock | $ 96.00 | |
500 mg | In stock | $ 162.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1. |
Cell Research | Exponentially growing cells (LoVo and HT-29 cells) are seeded in 20 cm2 Petri dishes with an optimal cell number for each cell line (2 × 104 for LoVo cells, 105 for HT-29 cells). They are treated 2 days later with increasing concentrations of Irinotecan or SN-38 for one cell doubling time (24 hours for LoVo cells, 40 hours for HT-29 cells). After washing with 0.15 M NaCl, the cells are further grown for two doubling times in normal medium, detached from the support with trypsin-EDTA and counted in a hemocytometer. The IC50 values are then estimated as the Irinotecan or SN-38 concentrations responsible for 50% growth inhibition as compared with cells incubated without Irinotecan or SN-38. (Only for Reference) |
Source |
Synonyms | Irinotecan HCl Trihydrate, CPT-11 HCl Trihydrate |
Molecular Weight | 677.18 |
Formula | C33H45ClN4O9 |
CAS No. | 136572-09-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 1 mg/mL (1.47 mM)
Ethanol: 7 mg/mL (10.33 mM)
DMSO: 93 mg/mL (137.3 mM)
You can also refer to dose conversion for different animals. More
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