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Search Results for " ikzf3 "

8

Compounds

Cat No. Product Name Synonyms Targets
T60024 CFT7455 Cemsidomide Ligand for E3 Ligase
CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ...
T22922 Lenalidomide hemihydrate TNF , Ligand for E3 Ligase , Molecular Glues
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.
T10765 Eragidomide CC-90009,Cereblon modulator 1 Apoptosis , Ligand for E3 Ligase , Molecular Glues
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
T1642 Lenalidomide CC-5013 Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T13721 Homo-PROTAC cereblon degrader 1 Others , Ligand for E3 Ligase
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
T73463 NX-2127 NX2127,NX 2127 BTK
NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 ...
T81942 Lenalidomide sodium CC-5013 sodium
Lenalidomide (sodium), a Thalidomide derivative, serves as a molecular glue and an orally active immunomodulator. It acts as a cereblon (CRBN) ligand and triggers selective ubiquitination and subsequent degradation of th...
T21763 Lenalidomide hydrochloride
Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facili...
TargetMol