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Search Results for " huntington "

6

Compounds

Cat No. Product Name Synonyms Targets
T7147 Valbenazine NBI-98854 Monoamine Transporter
Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.
T1110 Meclizine dihydrochloride Meclozine dihydrochloride,NSC28728,Meclizine 2HCl Apoptosis , Histamine Receptor
Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
T8081 LC3-mHTT-IN-AN1 Others , Autophagy , ATTECs
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner...
T7352 Pridopidine ACR16,ASP2314,FR310826 Dopamine Receptor
Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.
TN1140 Onjisaponin B AMPK , mTOR , Autophagy
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...
T74247 TPE-MI
Tetraphenylethene maleimide (TPE-MI) serves as a thiol probe to assess unfolded protein levels and proteostasis within cells. It is particularly effective in identifying proteostasis imbalances in both induced pluripoten...
TargetMol