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Pridopidine

Catalog No. T7352 CAS 346688-38-8

Synonyms: ACR16, ASP2314, FR310826

Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.

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Pridopidine, CAS 346688-38-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 229.00
50 mg	In stock	$ 343.00
100 mg	In stock	$ 497.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.89%

Purity: 95.2%

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Storage & Solubility Information

Description	Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.
Targets&IC50	σ1 receptor:70-80 nM (Ki)
In vivo	The actions of pridopidine were mediated by S1R and led to normalization of ER Ca2+ release, ER Ca2+ levels and spine SOC entry in YAC128 MSNs. This is a new potential mechanism of action for pridopidine, highlighting S1R as a potential target for HD therapy. Upregulation of striatal proteins that regulate calcium, including calbindin and homer1a, upon chronic therapy with pridopidine, may further contribute to long-term beneficial effects of pridopidine in HD[1].
Animal Research	Sprague Dawley rats (n = 6) were treated daily by oral gavage with pridopidine (60 mg/kg) over 10 days. Six control Sprague Dawley rats were vehicle-treated. On the 10th day, 90 min following the last drug administration, brains were removed and RNA was isolated from the striatum of each rat and was analyzed using Affymetrix Rat 230_2 arrays. The gene expression data from 12 striatum samples was RMA normalized with affy package v1.42.3 in R v3.1.2. Probesets were annotated . The limma package v3.18.13 in R v3.1.3 was used to test if relevant calcium-related genes were differentially expressed between the two groups of biological replicates and multiple hypothesis testing was corrected for using the Bonferroni correction. Limma employs an empirical Bayes method to moderate standard error . When a gene had multiple probesets, the probeset with the highest absolute value of fold change was reported[1].

Synonyms	ACR16, ASP2314, FR310826
Molecular Weight	281.41
Formula	C15H23NO2S
CAS No.	346688-38-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (177.68 mM)

References and Literature

1. Ryskamp D , Wu J , Geva M , et al. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease[J]. Neurobiology of Disease, 2016, 97(Pt A):46-59. 2. Shannon, Kathleen M . Pridopidine for the treatment of Huntington’s disease[J]. Expert Opinion on Investigational Drugs, 2016:1-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library NO PAINS Compound Library

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Keywords

Pridopidine 346688-38-8 GPCR/G Protein Neuroscience Dopamine Receptor inhibit FR-310826 ACR16 Inhibitor ASP2314 ACR-16 ASP-2314 FR 310826 ACR 16 ASP 2314 FR310826 inhibitor

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