Search Result

Search Results for " hepsin "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T60812	Cathepsin X-IN-1		Cysteine Protease
	Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].		Cysteine Protease
T6015	Cathepsin Inhibitor 1		Cysteine Protease
	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.		Cysteine Protease
T37504L	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies...
T62659	Cathepsin C-IN-4
	Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).
T72296	Cathepsin K inhibitor 3
	Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA).
T37504	Cathepsin D and E FRET Substrate
	Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.
T80052	Cathepsin B
	Cathepsin B, a cysteine protease, plays a role in various forms of programmed cell death, such as apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death [1].
T79496	Cathepsin C-IN-6
	Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase activation. This compound demonstrates potential efficacy in tr...
T11554	Cathepsin Inhibitor 2		Cysteine Protease
	Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).		Cysteine Protease
T63854	Cathepsin C-IN-3
	Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).
T80333	Cathepsin G(1-5)
	Cathepsin G(1-5), an antimicrobial peptide identified within the clostripain-digested cathepsin G mixture [1], exhibits bactericidal properties.
T38254	Cathepsin D and E FRET Substrate acetate
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, without activity towards cathepsins B, H, or L. This specificity makes it an essent...
T64159	Cathepsin K inhibitor 2
	Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K (Cat K) is a cysteine protease expressed under the control of the CTSK gene, which is closely related to osteoporosis and hydrolyses collagen. cat...
T72569	Cathepsin L/S-IN-1
	Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv...
T62494	Cathepsin C-IN-5
	Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S,...
T25492	Hepln-13	Hepln 13,Hepln13	c-Met/HGFR
	Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.		c-Met/HGFR
T5478	SRI 31215 TFA	SRI 31215	c-Met/HGFR
	SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,		c-Met/HGFR
T74390	VD2173
	VD2173, a macrocyclic peptide inhibitor with a side chain cyclization, effectively inhibits HGF-activating serine proteases including matriptase and hepsin, and is utilized in lung cancer research [1].
T40652	Meclizine	Meclozine	Histamine Receptor
	Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ...		Histamine Receptor

Compounds

Cathepsin X-IN-1

T60812

Synonym:

Target: Cysteine Protease

Cathepsin Inhibitor 1

T6015

Synonym:

Target: Cysteine Protease

Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

T37504L

Synonym: Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

Cathepsin K inhibitor 3

T72296

Synonym:

Target:

Cathepsin D and E FRET Substrate

Cathepsin Inhibitor 2

T11554

Synonym:

Target: Cysteine Protease

Cathepsin D and E FRET Substrate acetate

T38254

Synonym:

Target:

Cathepsin K inhibitor 2

Synonym: Hepln 13,Hepln13

Target: Histamine Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00778	HPN Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HPN Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 42 kDa and the accession number is P05981.
TMPK-00724	HPN Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	HPN Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 42.2 kDa and the accession number is O35453-1.
TMPY-00731	Cathepsin B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A024R374.
TMPY-02450	Cathepsin D Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P07339.
TMPY-02751	Cathepsin S Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin S Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is AAB94925.1.
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin S Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P25774-1.
TMPY-00734	Cathepsin L Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin L Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is A0A024R276.
TMPH-02566	Cathepsin W Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	May have a specific function in the mechanism or regulation of T-cell cytolytic activity. Cathepsin W Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre...
TMPY-00732	Cathepsin C Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno...
TMPH-03261	Cathepsin D Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Cathepsin D Protein, Rat, Recombinant (His & Myc) is exp...
TMPH-01063	Cathepsin O Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predic...
TMPH-00134	AcMNPV Viral cathepsin Protein (His & SUMO)	AcMNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. Accumulates within infected cells as an inactive proenzyme (proV-CATH), which is activated by proteo...
TMPY-01450	Cathepsin A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.8 kDa and the accession number is P16675-1.
TMPY-02144	Cathepsin B Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.6 kDa and the accession number is P10605.
TMPY-02171	Cathepsin L Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin L Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is P06797.
TMPH-00060	ApNPV Viral cathepsin Protein (His & Myc)	ApNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. ApNPV Vir...
TMPY-00362	Cathepsin S Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Cathepsin S Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa.
TMPH-01061	Cathepsin K Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPY-04503	Cathepsin B Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Cathepsin B Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.1 kDa and the accession number is F7FAT8.
TMPH-01060	Cathepsin F Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Cathepsin F Protein, Human, Recombinant (His) is expressed...
TMPH-02628	Cathepsin C Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
TMPH-00437	Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO)	Chinese hamster	E. coli
	N/A. Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 53.3 kDa and the accession number is G3I4W7.
TMPY-04081	Cathepsin H Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein,...
TMPY-00736	Cathepsin Z Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin Z Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.2 kDa and the accession number is Q545I6.
TMPY-00733	Cathepsin D Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin D Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.4 kDa and the accession number is P18242.
TMPY-00730	Cathepsin A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53 kDa and the accession number is P10619-1.
TMPH-03263	Cathepsin Z Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
TMPY-02699	Cathepsin Z Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin Z Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33 kDa and the accession number is Q9UBR2.
TMPH-01062	Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag...
TMPY-00439	Cathepsin E Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Cathepsin E Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.1 kDa and the accession number is AAH62002.1.
TMPH-01059	Cathepsin B Protein, Human, Recombinant (GST)	Human	E. coli
	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobuli...
TMPH-02565	Cathepsin K Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thy...
TMPY-06479	Cathepsin H Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein,...
TMPH-03262	Cathepsin K Protein, Rat, Recombinant (His)	Rat	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPY-01249	Cathepsin V Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...
TMPY-01699	Cathepsin E Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Cathepsin E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is P70269.