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SRI 31215 TFA

Catalog No. T5478 CAS 1832686-44-8

Synonyms: SRI 31215

SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,

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SRI 31215 TFA, CAS 1832686-44-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
2 mg	In stock	$ 88.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 459.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 977.00
1 mL * 10 mM (in DMSO)	In stock	$ 173.00

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Purity: 99.97%

Purity: 99.36%

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Description	SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,
Targets&IC50	Hepsin:0.65 μM , HGFA:0.3 μM, Matriptase:0.69 μM
In vitro	SRI 31215 inhibits fibroblast-induced MET activation, epithelial-mesenchymal transition and migration of cancer cells.?SRI 31215 overcomes primary resistance to cetuximab and gefitinib in HGF-producing colon cancer cells and prevents fibroblast-mediated resistance to EGFR inhibitors.?Thus, SRI 31215 blocks signaling between cancer cells and fibroblasts and inhibits the tumor-promoting activity of cancer-associated fibroblasts.
Cell Research	DU145 cells were cultured in 6-well tissue culture plates at a density of 1 103 cells per well.?After colonies formed (6-8 days), cells were serum-starved overnight and were then treated with recombinant HGF (10 ng/ml) or with conditioned media from 18Co fibroblasts in the presence or absence of SRI 31215 (10 μM) or the MET kinase inhibitor JNJ 38877605 (1 μM) for 24 hours.?Cells were washed with PBS and colonies were fixed and stained with 0.5% crystal violet solution in 6% glutaraldehyde.

Synonyms	SRI 31215
Molecular Weight	533.6
Formula	C27H34F3N5O3
CAS No.	1832686-44-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (38.6 mM)

References and Literature

1. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Neural Regeneration Compound Library Cytokine Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Lung Cancer Compound Library Reprogramming Compound Library Bioactive Compound Library

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Keywords

SRI 31215 TFA 1832686-44-8 Tyrosine Kinase/Adaptors c-Met/HGFR SRI-31215 SRI 31215 inhibit SRI31215 Inhibitor inhibitor

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