Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 563.00 | |
100 mg | In stock | $ 812.00 | |
500 mg | In stock | $ 1,670.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
Targets&IC50 | Cathepsin L2:6.7(pIC50), Cathepsin B:5.2(pIC50), Cathepsin S:6(pIC50), Cathepsin K:5.5(pIC50), Cathepsin L:7.9(pIC50) |
In vivo | Ciproxifan intravenously injected at dose of 1 mg/kg decreases the H3-receptor ligand concentration in serum in Male Swiss mice, with half-times of distribution phase of 13min and elimination phase of 87 min, respectively. Ciproxifan (1 mg/kg, p.o.) rises brain t-MeHA level rapidly in Male Swiss mice, being already significantly increased after 30 min, reaching a plateau between 90 and 180 min and still remaining enhanced after 270 min. Ciproxifan leads to ED50 values of 0.23 mg/kg in cerebral cortex, 0.28 mg/kg in striatum and 0.30 mg/kg in hypothalamus in Male Wistar rats. Ciproxifan (3 mg/kg, i.p.) significantly increases choice accuracy as evaluated in the five-choice task performed using a short stimulus duration. Ciproxifan (0.15-2 mg/kg, p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats. [1] Ciproxifan (10 mg/kg i.p.) enhances prepulse inhibition in the DBA/2 strain mice. [3] Ciproxifan (3 mg/kg i.p.) alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. [4] Ciproxifan (3 mg/kg i.p.) improves accuracy and decreased impulsivity in adult male hooded Lister rats. [5] |
Molecular Weight | 401.89 |
Formula | C20H24ClN5O2 |
CAS No. | 225120-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 74 mg/mL (184.1 mM)
Ethanol: 47 mg/mL (116.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cathepsin Inhibitor 1 225120-65-0 Proteases/Proteasome Cysteine Protease Cathepsin Inhibitor CatK CatB CatL Cathepsin inhibitor-1 inhibit CatL2 Cathepsin inhibitor1 CatS inhibitor