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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8869 | B355252 | Others | |
B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth. | |||
T126461 | Aloenin B | ||
Aloenin B, a compound isolated from the leaves and roots of Aloe vera, has neuroprotective activity against glutamate-induced neuronal death in HT22 cells. | |||
T14991 | CMS-121 | CMS121 | Acetyl-CoA Carboxylase |
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotect... | |||
T6S0654 | Isocorynoxeine | 7-Isocorynoxeine | 5-HT Receptor |
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
TN1601 | Effusol | Caspase | |
Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampa... | |||
T36516 | RC574 | RC574 | |
RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons... | |||
T36515 | RC363 | ||
RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a... | |||
TN4679 | Nudiposide | IL Receptor , TNF | |
Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α,... | |||
T83404 | 2,5-Dihydroxy-4-methoxyacetophenone | ||
Compound 3, 2,5-Dihydroxy-4-methoxyacetophenone, is isolated from the 80% methanol extract of the roots of Cynanchum paniculatum Kitagawa and has been shown to inhibit glutamate-induced cytotoxicity in the hippocampal HT... | |||
TN1361 | (+)-Afzelechin | Others | |
(+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM | |||
TN1814 | Juncusol | Caspase , Antifection | |
Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows signific... | |||
TN4580 | Morachalcone A | Tyrosinase | |
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-... | |||
T71870 | CP21 | ||
CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephri... |