erlotinib — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0373	Erlotinib	OSI-744,NSC 718781,CP358774,R1415	EGFR , Autophagy
	Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.		EGFR , Autophagy
T6328	Desmethyl Erlotinib	OSI-420,CP-473420,O-Desmethyl Erlotinib	EGFR , Drug Metabolite
	Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).		EGFR , Drug Metabolite
T0373L	Erlotinib hydrochloride	OSI-744,NSC 718781,Erlotinib HCl,CP-358774	EGFR , Autophagy
	Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.		EGFR , Autophagy
T6619	Desmethyl Erlotinib hydrochloride	OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,CP-473420,Desmethyl Erlotinib,OSI 420	EGFR , Drug Metabolite
	Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells...		EGFR , Drug Metabolite
T35915	Erlotinib-13C6	Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumo...
T19312	Erlotinib-d6 hydrochloride	CP-358774 D6 hydrochloride,NSC 718781 D6 hydrochloride,Erlotinib D6 hydrochloride,OSI-774 D6 hydrochloride	Others
	Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.		Others
T11229	Erlotinib-d6	OSI-774 D6,NSC 718781 D6,CP-358774 D6	Others
	Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .		Others
T0373L1	Erlotinib mesylate	CP-358774,CP-358,774,OSI-774,CP358774,OSI 774
	Erlotinib is an epidermal growth factor receptor inhibitor. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor.
T31055	CP-457493	OSI-493,Erlotinib metabolite M6,CP457493,UNII-X0JH558S7E
	CP-457493 is a bio-active chemical.
T35528	TD52		Apoptosis , Phosphatase , Akt
	TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter.		Apoptosis , Phosphatase , Akt
T35528L	TD52 dihydrochloride	TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali...		Others
T73472	Erasin
	Erasin, a formidable antagonist to Erlotinib resistance, selectively inhibits STAT3 with an IC50 of 9.7 μM, and STAT1 with an IC50 of 24 μM. It effectively induces apoptosis in cancer cells [1].
T34892	TM608	TM-608,TM 608
	TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-re...
T22343	HKB99		Others
	HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, could suppresse tumor growth and metastasis and overcome erlotinib resistance in non-small-cell lung cancer (NSCLC)		Others
T71526	CH5164840
	CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combin...
T35147	WZ4002-hydroxy	WZ4002 analog, WZ4002 demethyl derivate,WZ 4002-hydroxy,WZ-4002-hydroxy
	WZ4002-hydroxyl is a WZ4002 derivative or WZ4002 analogue in which methoxy is replaced by hydroxyl and can be detected in 50% of patients with clinical resistance to gefitinib or erlotinib. WZ4002 has a basic chemical sk...
T36102	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone dea...
T69888	SB02024
	SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 a...