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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Catalog No. T36102 CAS 183322-18-1

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Structure

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline, CAS 183322-18-1

Pack Size	Availability	Price/USD
25 mg	5 days	$ 51.00
50 mg	5 days	$ 101.00
100 mg	5 days	$ 182.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	312.75
Formula	C14H17ClN2O4
CAS No.	183322-18-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL

Ethanol: 1 mg/mL

DMF:PBS (pH 7.2) (1:4): 0.20 mg/mL

DMF: 30 mg/mL

References and Literature

1. Pandey, A., Volkots, D.L., Seroogy, J.M., et al.Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase familyJ. Med. Chem.45(17)3772-3793(2002) 2. Li, W.W., Wang, X.Y., Zheng, R.L., et al.Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3-morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivoJ. Med. Chem.55(8)3852-3866(2012) 3. Zhang, X., Su, M., Chen, Y., et al.The design and synthesis of a new class of RTK/HDAC dual-targeted inhibitorsMolecules18(6)6491-6503(2013) 4. Liu, Z., Wang, L., Feng, M., et al.New acrylamide-substituted quinazoline derivatives with enhanced potency for the treatment of EGFR T790M-mutant non-small-cell lung cancersBioorg. Chem.77593-599(2018) 5. Knesl, P., R?seling, D., and Jordis, U.Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: Tandutinib, erlotinib and gefitinibMolecules11(4)286-297(2006)

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 183322-18-1 4 Chloro 6,7 bis(2 methoxyethoxy)quinazoline 4Chloro6,7bis(2methoxyethoxy)quinazoline inhibitor inhibit

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