egfr-in-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63732	EGFR-IN-3		Apoptosis , EGFR
	EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase.		Apoptosis , EGFR
TQ0255	Olafertinib	CK-101,EGFR-IN-3,RX-518	EGFR
	Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.		EGFR
T12131	Mutated EGFR-IN-3		EGFR
	Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM and 13 nM, respectively. )		EGFR
T62777	EGFR/HER2-IN-3
	EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.
T79394	ALK/EGFR-IN-3
	ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-EML4-ALK, with respective IC50 values of 0.1360, 0.0332, and...
T79728	EGFR/CDK2-IN-3		EGFR
	EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively. It prompts apoptosis in MCF-7 cells and halts the cell cycle in the S p...		EGFR
T78850	EGFR/BRAFV600E-IN-3		EGFR
	EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively. It induces apoptosis and exhibits promising antioxidant activity [1].		EGFR
T63161	EGFR/HER2/CDK9-IN-3
	EGFR/HER2/CDK9-IN-3 (Compound 10) is a potent inhibitor of EGFR (IC50:191.08 nM), HER2 (IC50:132.65 nM), and CDK9 (IC50:113.98 nM). EGFR/HER2/CDK9-IN-3 showed significant anti-tumor effects.
T82492	EGFR/HER2/DHFR-IN-3		EGFR
	EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.092 μM for HER2, respectively. Moreover, it demonstrates inhi...		EGFR
T5437	Gefitinib-based PROTAC 3		EGFR
	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...		EGFR
T4657L	WHI-P97 HCl 211555-05-4(free base)		JAK
	WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively ...		JAK
TJS0339	Coumarin-3-carboxylic acid	3-Carboxycoumarin	VEGFR
	The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination ma...		VEGFR
T74351	PROTAC EGFR degrader 3
	PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome's crucial role in the degradation...
T72431	Theliatinib tartrate	Xiliertinib tartrate,HMPL-309 tartrate,Xiliertinib tartrate ; HMPL-309 tartrate
	Theliatinib (Xiliertinib) tartrate is a potent and highly selective EGFR inhibitor, displaying ATP-competitive and orally active properties. It exhibits promising efficacy with a K_i of 0.05 nM and an IC_50 of 3 nM for E...
T62681	PDE5-IN-3
	PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM). PDE5-IN-3 has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). PDE5-IN-3 markedly inhibits the Wnt/β-catenin pathway with an IC50 value of 128...
T82493	EGFR/HER2/DHFR-IN-2		EGFR
	EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively. It exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.1...		EGFR
T28874	SU11652	SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF...
T70128	Olmutinib hydrochloride
	Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently...
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f...
T76721	Zalutumumab
	Zalutumumab, a fully human IgG1 monoclonal antibody, exhibits high affinity for the epidermal growth factor receptor (EGFR), selectively targeting its domain III. It functions by inhibiting the binding of the epidermal g...