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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8747 | Levofloxacin hydrochloride | DNA gyrase , Topoisomerase | |
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh... | |||
T78866 | DNA Gyrase-IN-9 | DNA/RNA Synthesis | |
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase. It exhibits a minimum inhibitory concentration (MIC) of 0.5-2 µg/mL for Gram-positive bacteria inhibition and a minimum bactericidal ... | |||
T62895 | DNA Gyrase-IN-4 | ||
DNA Gyrase-IN-4 (compound 8p) is a potent inhibitor of DNA cyclooxygenase (IC50: 0.13 μM). (MIC: 0.05 μg/ml), Salmonella (MIC: 0.05 μg/ml) and Escherichia coli (MIC: 8 μg/ml). | |||
T63442 | DNA Gyrase-IN-2 | ||
DNA Gyrase-IN-2 is a bacterial DNA cyclooxygenase B inhibitor that acts on Escherichia coli DNA cyclooxygenase (IC50: 3.29-10.49 μM) and Mycobacterium tuberculosis DNA cyclooxygenase (IC50: 4.41-5.61 μM), exhibiting anti... | |||
T61937 | DNA Gyrase-IN-3 | ||
DNA Gyrase-IN-3 (Compound 28) is an inhibitor of bacterial DNA gyrase B. The IC50 of DNA Gyrase-IN-3 inhibits Escherichia coli DNA rotatase is 5.41-15.64 μM. DNA Gyrase-IN-3 shows anti-tuberculosis and antibacterial acti... | |||
T63395 | DNA Gyrase-IN-5 | ||
DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains. | |||
T63681 | DNA Gyrase-IN-1 | ||
DNA Gyrase-IN-1 is a potent and selective DNA promoter inhibitor (IC50: 2.6 μM). DNA Gyrase-IN-1 inhibits Mycobacterium tuberculosis (Mtb) activity well (MIC: 0.49 μM). DNA Gyrase-IN-1 can be used to study tuberculosis. | |||
T78712 | DNA Gyrase-IN-8 | DNA/RNA Synthesis | |
DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1]. | |||
T74848 | DNA Gyrase-IN-6 | ||
Antibacterial agent 138, a benzothiazole inhibitor, targets bacterial DNA gyrase and topoisomerase IV, exhibiting both favorable solubility and plasma protein binding. It demonstrates antibacterial activity against Gram-... | |||
T13231L | Trovafloxacin mesylate | Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial | |
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ... | |||
T79240 | DNA gyrase B-IN-2 | ||
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition ... | |||
T64012 | DNA gyrase B-IN-1 | ||
DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM). | |||
T78776 | DNA gyrase B-IN-3 | DNA/RNA Synthesis | |
DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1]. | |||
T6567 | Levofloxacin | Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin | Topoisomerase , Antibacterial , Antibiotic |
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections. | |||
T62792 | 14α-Demethylase/DNA Gyrase-IN-1 | ||
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity. | |||
T62389 | 14α-Demethylase/DNA Gyrase-IN-2 | ||
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity. | |||
T7865 | Danofloxacin | Danofloxacino,Danofloxacin free base,Danofloxacine | Others , DNA/RNA Synthesis , Antibacterial , Antibiotic |
Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine. | |||
T0909 | Nalidixic acid | NSC-82174 | Topoisomerase , Antibacterial , Antibiotic |
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE. | |||
T0717L | Enoxacin | NSC 629661,AT 2266,Pd107779,CI 919 | DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic |
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | |||
T1451 | Levofloxacin hydrate | Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate | DNA gyrase , Topoisomerase , Antibacterial , Antibiotic |
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c... |