Home Tools
Log in
Cart

Search Result

Search Results for " cyclopamine "

10

Compounds

Cat No. Product Name Synonyms Targets
T2825 Cyclopamine 11-Deoxojervine Hedgehog/Smoothened , Endogenous Metabolite , Smo
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T35558 KAAD-Cyclopamine
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...
T23027 MRT-10 Hedgehog/Smoothened
MRT-10 is a Smoothened (Smo) receptor antagonist.
T9532 MRT-81 Others
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...
T2299 BMS-833923 XL-139 Apoptosis , Hedgehog/Smoothened , Smo
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T1810 Purmorphamine Shh Signaling Antagonist VI Hedgehog/Smoothened , Smo , Autophagy
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T4592 TOMATIDINE HYDROCHLORIDE Tomatidine,Tomatidine HCl Others , NF-κB , JNK , Autophagy
Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatid...
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.
T38767 MRT-83 hydrochloride
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t...
T71338 Patidegib HCl
Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specific...
TargetMol