ck1ε — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4646	TA-02		p38 MAPK , Autophagy
	TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.		p38 MAPK , Autophagy
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T3972	SR-3029	SR3029	Casein Kinase
	SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.		Casein Kinase
T5393	CK1-IN-1	PUN51207	p38 MAPK , Casein Kinase
	CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.		p38 MAPK , Casein Kinase
T5056	PF-4800567		Casein Kinase
	PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.		Casein Kinase
T3073	PF-670462	PF670462	Casein Kinase
	PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.		Casein Kinase
T4645	TA-01		p38 MAPK , Casein Kinase , Autophagy
	TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.		p38 MAPK , Casein Kinase , Autophagy
T4976	Umbralisib	TGR-1202,RP5264,TGR 1202,TGR1202	PI3K
	Umbralisib (TGR 1202) is a PI3Kδ inhibitor.		PI3K
T74661	MU1742
	MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .
T1877	LH846	LH-846,LH 846	Casein Kinase
	LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.		Casein Kinase
T17066	Umbralisib hydrochloride	RP5264 hydrochloride,TGR-1202 hydrochloride	PI3K
	Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM).		PI3K
T21650	IWP-3
	IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 moderately inhibits CK1γ3 and CK1ε while not inhibit...
T72465	Umbralisib tosylate	RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate
	Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it...
T72527	Umbralisib sulfate	TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate
	Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. It demonstrates u...