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LH846

Name: LH846
Brand: TargetMol
SKU: T1877
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1877Cas No. 639052-78-1

Alias LH-846, LH 846

LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.

LH846

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Purity: 98.26%

Catalog No. T1877Alias LH-846, LH 846Cas No. 639052-78-1

LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$58	In Stock	In Stock
10 mg	$79	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$247	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.26%

Appearance:Solid

Color:White to Purple

Resource Download

COA LCMS HNMR

Product Introduction

LH846 AI Summary

LH846 displays antiviral activity by inhibiting the cytotoxic effects of SARS-CoV-2 in Caco-2 and VERO-6 cells, showing an inhibition rate of 4.44% and -0.15% respectively at a concentration of 10 µM after 48 hours as determined by high-content imaging. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 13.59% at 20 µM as detected through FRET response from a peptide substrate. Furthermore, LH846 demonstrates potential as a human HDAC6 enzyme inhibitor, with inhibitions of 19.68% and 1.03% using commercial and custom peptide substrates in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.
Targets&IC50	CK1ε:1.3 μM, CK1α:2.5 μM, CK1δ:290 nM
Synonyms	LH-846, LH 846

Chemical Properties

Molecular Weight	316.81
Formula	C₁₆H₁₃ClN₂OS
Cas No.	639052-78-1
Smiles	Cc1cc2sc(NC(=O)Cc3ccccc3)nc2cc1Cl
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (173.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1565 mL	15.7823 mL	31.5647 mL	157.8233 mL
5 mM	0.6313 mL	3.1565 mL	6.3129 mL	31.5647 mL
10 mM	0.3156 mL	1.5782 mL	3.1565 mL	15.7823 mL
20 mM	0.1578 mL	0.7891 mL	1.5782 mL	7.8912 mL
50 mM	0.0631 mL	0.3156 mL	0.6313 mL	3.1565 mL
100 mM	0.0316 mL	0.1578 mL	0.3156 mL	1.5782 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc