Search Result

Search Results for " ce1 "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T62719	AChE/BACE1/GSK3β-IN-1
	AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T10453	BACE1-IN-5		Beta Amyloid , BACE
	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...		Beta Amyloid , BACE
T79022	BACE1-IN-13		Beta-Secretase
	BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ...		Beta-Secretase
T63867	BACE1-IN-12
	BACE1-IN-12 is a potent BACE1 inhibitor (IC50: 8.9 μM) that can cross the blood-brain barrier. BACE1-IN-12 selectively inhibits BuChE (butylcholinesterase) activity (IC50: 3.2 μM). BACE1-IN-12 has potential for anti-Alzh...
T10450	BACE1-IN-1		BACE
	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).		BACE
T10451	BACE1-IN-2		BACE
	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).		BACE
T39484	BACE1-IN-6	BACE1-IN-6
	BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T61956	BACE1/2-IN-1
	BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T10452	BACE1-IN-4		BACE
	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.		BACE
T73076	BACE1-IN-10		Beta-Secretase
	BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].		Beta-Secretase
T64074	BACE1-IN-8
	BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).

Compounds

AChE/BACE1/GSK3β-IN-1

Target: Beta Amyloid, BACE

BACE1-IN-13

T79022

Synonym:

Target: Beta-Secretase

Target: Beta-Secretase

Cat No.	Product Name	Synonyms	Targets
T75541	Tanshinone IIA anhydride
	Tanshinone IIA anhydride is a potent, irreversible inhibitor of human carboxylesterase (CE), exhibiting inhibitory constants (K i values) of 1.9 nM for human CE1 and 1.4 nM for human intestinal CE (hiCE), respectively [1...
T5722	Nevadensin	Pedunculin	Anti-infection , Antibacterial
	Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition acti...		Anti-infection , Antibacterial

Natural Products

Tanshinone IIA anhydride

Target: Anti-infection, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06754	CES1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CES1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.08 kDa and the accession number is NP_001020365.
TMPY-01929	ECE1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Endothelin-converting enzyme 1, also known as ECE-1, is a single-pass type II membrane protein which belongs to thepeptidase M13 family. ECE-1 converts big endothelin-1 to endothelin-1. ECE-1 is a membrane metalloprot...
TMPY-00752	BACE1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.9 kDa and the accession number is A0A024R3D7.
TMPY-00651	BACE1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75 kDa and the accession number is A0A024R3D7.
TMPY-00652	BACE1 Protein, Human, Recombinant	Human	HEK293 Cells
	BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.
TMPY-00678	BACE1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	BACE1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is P56818.