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Nevadensin

Catalog No. T5722   CAS 10176-66-6
Synonyms: Pedunculin

Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL.

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Nevadensin Chemical Structure
Nevadensin, CAS 10176-66-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 64.00
25 mg In stock $ 115.00
50 mg In stock $ 188.00
100 mg In stock $ 283.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL.
Targets&IC50 hCE2:132.8 μM (IC50), hCE1:2.64 μM (IC50)
In vitro The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which forms DNA adducts. METHODS AND RESULTS: This study investigated whether the inhibitory effect of the basil flavonoid Nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. Co-exposure to methyleugenol and Nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. CONCLUSIONS: These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as Nevadensin compared to experiments using the pure methyleugenol.
Source
Synonyms Pedunculin
Molecular Weight 344.32
Formula C18H16O7
CAS No. 10176-66-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.71 mg/mL (42.72 mM), sonification is recommended.

TargetMolReferences and Literature

1. The natural basil flavonoid nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. Food Chem Toxicol. 2014 Dec;74:28-34. 2. Antimycobacterial and antioxidant flavones from Limnophila geoffrayi. Arch Pharm Res. 2003 Oct;26(10):816-20.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library RO5 Drug-like Natural Product Library Inhibitor Library Selected Plant-Sourced Compound Library Bioactive Compound Library Anti-Obesity Compound Library Anti-Bacterial Compound Library Bioactive Compounds Library Max Anti-Tumor Natural Product Library Natural Product Library for HTS

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Keywords

Nevadensin 10176-66-6 Microbiology/Virology Anti-infection Antibacterial pharmacological selective Pedunculin Inhibitor flavonoid effect Bacterial natural inhibit inhibition inhibitor

 

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