Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 115.00 | |
50 mg | In stock | $ 188.00 | |
100 mg | In stock | $ 283.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. |
Targets&IC50 | hCE2:132.8 μM (IC50), hCE1:2.64 μM (IC50) |
In vitro | The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which forms DNA adducts. METHODS AND RESULTS: This study investigated whether the inhibitory effect of the basil flavonoid Nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. Co-exposure to methyleugenol and Nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. CONCLUSIONS: These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as Nevadensin compared to experiments using the pure methyleugenol. |
Source |
Synonyms | Pedunculin |
Molecular Weight | 344.32 |
Formula | C18H16O7 |
CAS No. | 10176-66-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.71 mg/mL (42.72 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Nevadensin 10176-66-6 Microbiology/Virology Anti-infection Antibacterial pharmacological selective Pedunculin Inhibitor flavonoid effect Bacterial natural inhibit inhibition inhibitor