brigatinib — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3621	Brigatinib	AP-26113	EGFR , FLT , ROS , IGF-1R , ALK
	Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.		EGFR , FLT , ROS , IGF-1R , ALK
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T74489	SIAIS117
	SIAIS117, a potent Brigatinib-PROTAC degrader, effectively degrades the ALK G1202R point mutation through its design based on Brigatinib and VHL-1 conjunction. It inhibits the proliferation of SR and H2228 cancer cell li...
T74570	SIAIS164018
	SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cy...
T77942	SIAIS164018 hydrochloride		PROTACs
	SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It effectively suppresses cancer cell migration and invasion, induces G1 ce...		PROTACs