Angiogenesis FLT Brigatinib


Catalog No. T3621   CAS 1197953-54-0
Synonyms: AP-26113

Brigatinib is a highly potent and selective ALK inhibitor.

Brigatinib, CAS 1197953-54-0
Pack Size Availability Price/USD Quantity
1 mg In stock 24.00
2 mg In stock 29.00
5 mg In stock 50.00
10 mg In stock 70.00
25 mg In stock 98.00
50 mg In stock 130.00
100 mg In stock 190.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Brigatinib is a highly potent and selective ALK inhibitor.
Targets&IC50 ALK : ic50 0.37nM,   EGFR (C797S/del19) : ic50 39.9nM,   FLT3 : ic50 2.1nM,   IGF-1R : ic50 24.9nM,   ROS1 : ic50 1.9nM,  
Kinase Assay In vitro HotSpotSM kinase profiling of 289 kinases is performed. The assay is conducted in the presence of 10 μM [33P]-ATP, using brigatinib concentrations ranging from 0.05 nM to 1 μM.
Cell Research
All cell lines were used within 20 passages of the initial thaw. Following inhibitor treatment for 72 h, cell growth was assessed to determine the concentration that causes 50% inhibition of cell viability (IC50). (Only for Reference)
Cell lines: U937 cells, Karpas-299 cells, H3122 cells
Animal Research
Animal Model: feCD rats
Synonyms AP-26113
Purity 98.00%
Molecular Weight 584.09
Formula C29H39ClN7O2P
CAS No. 1197953-54-0


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: Insoluble

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964. 2. Uchibori, K et al. Nat. Commun. 8, 14768 doi: 10.1038/ncomms14768 (2017). 3. Zhang S, et al. The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models. Clin Cancer Res. 2016 Nov 15;22(22):5527-5538 4. Huang WS, et al. Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J Med Chem. 2016 May 26;59(10):4948-64. 5. Siaw JT, et al. Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice. Oncotarget. 2016 May 17;7(20):29011-22

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Tyrosine kinase inhibitor library FDA-approved Drug Library Immunology/Inflammation Compound Library Kinase Inhibitor Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library JAK STAT Compound Library

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