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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T18598 | PROTAC BRD2/BRD4 degrader-1 | Others | |
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its e... | |||
T8932 | GSK046 | iBET-BD2 | Epigenetic Reader Domain |
GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively). It has immunom... | |||
T2120 | I-BET151 | GSK1210151A | Epigenetic Reader Domain |
I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays). | |||
T26897 | BRD2492 | HDAC | |
BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, HDAC3 and HDAC6.BRD2492 inhibits the growth of breast cancer... | |||
T74406 | BRD2889 | ||
BRD2889, an analog of the alkaloid piperlongumine, serves as a potent modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) [1]. | |||
T26898 | BRD2879 | BRD 2879,BRD-2879 | |
BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM). | |||
T69645 | BRD20322 | ||
BRD20322 is a novel potent inhibitor of spCas9, disrupting spCas9-DNA binding and exerting dose and temporal control of spCas9 in human cell lines. | |||
T25176 | BRD2577 | BRD-2577,BRD 2577 | |
BRD2577 is an HDAC inhibitor, by suppressing multiple HDAC enzymes and modulating acetylation levels in cells. | |||
T5435 | ARV-771 | Epigenetic Reader Domain | |
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1]. | |||
T19935 | XD14 | Epigenetic Reader Domain | |
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively). | |||
T22345 | INCB054329 | INCB-054329,INCB-54329,INCB-54329 | Epigenetic Reader Domain |
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, ... | |||
T10638 | BY27 | Epigenetic Reader Domain | |
BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth. | |||
T6255 | Bromosporine | Epigenetic Reader Domain , CDK | |
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. | |||
T9703 | GSK778 | Epigenetic Reader Domain | |
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ... | |||
T4697 | ABBV-744 | ABBV744 | Epigenetic Reader Domain , HIV Protease |
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS. | |||
T6021 | GSK1324726A | I-BET726 | Apoptosis , Epigenetic Reader Domain |
GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM). | |||
T12112 | MS402 | Epigenetic Reader Domain | |
MS402 is a novel BD1-selective BET BrD inhibitor. | |||
TQ0253 | PLX51107 | Epigenetic Reader Domain | |
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1). | |||
T72058L | CDD-1102 HCl | CDD-1102 HCl(2757619-84-2 Free base) | Epigenetic Reader Domain |
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments. | |||
T9703L | GSK778 hydrochloride | Epigenetic Reader Domain | |
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 ... |